MicroRNAs regulate critical genes associated with multiple myeloma pathogenesis.

Proceedings of the National Academy of Sciences of the United States of America
Flavia PichiorriCarlo M Croce

Abstract

Progress in understanding the biology of multiple myeloma (MM), a plasma cell malignancy, has been slow. The discovery of microRNAs (miRNAs), a class of small noncoding RNAs targeting multiple mRNAs, has revealed a new level of gene expression regulation. To determine whether miRNAs play a role in the malignant transformation of plasma cells (PCs), we have used both miRNA microarrays and quantitative real time PCR to profile miRNA expression in MM-derived cell lines (n = 49) and CD138+ bone marrow PCs from subjects with MM (n = 16), monoclonal gammopathy of undetermined significance (MGUS) (n = 6), and normal donors (n = 6). We identified overexpression of miR-21, miR-106b approximately 25 cluster, miR-181a and b in MM and MGUS samples with respect to healthy PCs. Selective up-regulation of miR-32 and miR-17 approximately 92 cluster was identified in MM subjects and cell lines but not in MGUS subjects or healthy PCs. Furthermore, two miRNAs, miR-19a and 19b, that are part of the miR-17 approximately 92 cluster, were shown to down regulate expression of SOCS-1, a gene frequently silenced in MM that plays a critical role as inhibitor of IL-6 growth signaling. We also identified p300-CBP-associated factor, a gene involved in p53 r...Continue Reading

References

Mar 21, 2000·Biochimica Et Biophysica Acta·R L Schiltz, Y Nakatani
Sep 11, 2003·The Lancet Oncology·Sonja SeidlJohannes Drach
Dec 6, 2003·Science·Chang-Zheng ChenDavid P Bartel
Dec 31, 2003·Cell·Benjamin P LewisChristopher B Burge
Jun 24, 2004·Proceedings of the National Academy of Sciences of the United States of America·Chang-Gong LiuCarlo M Croce
Nov 16, 2004·International Journal of Hematology·Marcela OanceaAlexandru Almasan
Apr 5, 2005·Nature Genetics·Azra KrekNikolaus Rajewsky
Jun 10, 2005·Nature·Lin HeScott M Hammond
Jun 10, 2005·Nature·Kathryn A O'DonnellJoshua T Mendell
Jul 19, 2005·Cancer Research·Jennifer A ChanKenneth S Kosik
Oct 28, 2005·The New England Journal of Medicine·George Adrian CalinCarlo M Croce
Feb 8, 2006·Proceedings of the National Academy of Sciences of the United States of America·Stefano VoliniaCarlo M Croce
Jun 27, 2006·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Kurt BommertThorsten Stühmer
Oct 25, 2006·Nature Reviews. Cancer·George A Calin, Carlo M Croce
Feb 13, 2007·Nature Cell Biology·Laëtitia K LinaresMonsef Benkirane
Jul 25, 2007·Nature Reviews. Cancer·Teru HideshimaKenneth C Anderson
Nov 13, 2007·Hematology/oncology Clinics of North America·Rafael Fonseca, Jesus San Miguel
Dec 12, 2007·Best Practice & Research. Clinical Haematology·W J ChngW M Kuehl
Feb 1, 2008·The New England Journal of Medicine·Carlo M Croce
Mar 1, 2008·Proceedings of the National Academy of Sciences of the United States of America·Ramiro GarzonBrunangelo Falini
Apr 5, 2008·Nature Protocols·Chang-Gong LiuCarlo M Croce

❮ Previous
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Citations

Jun 10, 2011·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Guang YangShiguang Zhao
Mar 7, 2012·Medical Microbiology and Immunology·Yuanyuan ChenKe Zen
Feb 21, 2009·Apoptosis : an International Journal on Programmed Cell Death·Nikhil S ChariTimothy J McDonnell
May 4, 2010·Biogerontology·Johannes GrillariRegina Grillari-Voglauer
Mar 5, 2013·International Journal of Hematology·Marta Chesi, P Leif Bergsagel
Jul 16, 2011·Hormones & Cancer·Michael A TesselPreethi H Gunaratne
May 15, 2013·Cancer Letters·Julie Bienertova-VaskuOndrej Slaby
Feb 22, 2012·Expert Reviews in Molecular Medicine·Aliaa M SeoudiAhmed I Abdelaziz
Oct 3, 2009·Leukemia·R FonsecaUNKNOWN International Myeloma Working Group
Jun 28, 2011·Leukemia·S L CorthalsP Sonneveld
Apr 13, 2012·Nature Reviews. Cancer·Gareth J MorganFaith E Davies
Oct 5, 2010·Nature Reviews. Drug Discovery·Ramiro GarzonCarlo M Croce
Jun 8, 2011·Proceedings of the National Academy of Sciences of the United States of America·Xiaodong MaYong Li
Jun 11, 2009·The Journal of Biological Chemistry·Manjunatha R BenakanakereDenis F Kinane
Apr 8, 2010·The Journal of Biological Chemistry·Kun Wang, Pei-Feng Li
Jun 21, 2012·Carcinogenesis·Kwan Yeung WongChor Sang Chim
May 8, 2009·Nucleic Acids Research·Alexey V AntonovHans W Mewes
Jun 12, 2012·Nucleic Acids Research·Michael P GantierBryan R G Williams
Dec 17, 2009·The Cancer Journal·Jesus San-MiguelNorma C Gutierrez
Jun 1, 2012·The Cancer Journal·Christopher J Cheng, Frank J Slack
Dec 22, 2012·Leukemia Research and Treatment·Yao YuanElizabeth Raveche
Oct 12, 2012·International Journal of Vascular Medicine·Munekazu Yamakuchi
Mar 18, 2011·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Nikhil C Munshi, Hervé Avet-Loiseau
Apr 2, 2010·Acta Haematologica·Reinhold MunkerNyla Heerema
Oct 2, 2012·The Journal of Clinical Investigation·W Michael Kuehl, P Leif Bergsagel
Dec 18, 2012·The Journal of Clinical Investigation·Molly A TaylorWilliam P Schiemann

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