MicroRNAs regulate key cell survival pathways and mediate chemosensitivity during progression of diffuse large B-cell lymphoma

Blood Cancer Journal
Suvi-Katri LeivonenSirpa Leppä


Despite better therapeutic options and improved survival of diffuse large B-cell lymphoma (DLBCL), 30-40% of the patients experience relapse or have primary refractory disease with a dismal prognosis. To identify biological correlates for treatment resistance, we profiled microRNAs (miRNAs) of matched primary and relapsed DLBCL by next-generation sequencing. Altogether 492 miRNAs were expressed in the DLBCL samples. Thirteen miRNAs showed significant differential expression between primary and relapse specimen pairs. Integration of the differentially expressed miRNAs with matched mRNA expression profiles identified highly anti-correlated, putative targets, which were significantly enriched in cancer-associated pathways, including phosphatidylinositol (PI)), mitogen-activated protein kinase (MAPK), and B-cell receptor (BCR) signaling. Expression data suggested activation of these pathways during disease progression, and functional analyses validated that miR-370-3p, miR-381-3p, and miR-409-3p downregulate genes on the PI, MAPK, and BCR signaling pathways, and enhance chemosensitivity of DLBCL cells in vitro. High expression of selected target genes, that is, PIP5K1 and IMPA1, was found to be associated with poor survival in two ...Continue Reading


Jan 25, 2002·The New England Journal of Medicine·Bertrand CoiffierChristian Gisselbrecht
Jun 21, 2002·The New England Journal of Medicine·Andreas RosenwaldUNKNOWN Lymphoma/Leukemia Molecular Profiling Project
Apr 28, 2006·Proceedings of the National Academy of Sciences of the United States of America·Stefan CostineanCarlo M Croce
Oct 25, 2006·Nature Reviews. Cancer·George A Calin, Carlo M Croce
Jul 7, 2007·Molecular Cell·Andrew GrimsonDavid P Bartel
Sep 26, 2007·Nature Genetics·Michael KerteszEran Segal
Nov 10, 2007·Nucleic Acids Research·Sam Griffiths-JonesAnton J Enright
Jun 13, 2008·Nature Protocols·Thomas D Schmittgen, Kenneth J Livak
Aug 1, 2008·Nature·Daehyun BaekDavid P Bartel
Nov 29, 2008·The New England Journal of Medicine·G LenzUNKNOWN Lymphoma/Leukemia Molecular Profiling Project
May 2, 2009·Nucleic Acids Research·M MaragkakisA G Hatzigeorgiou
Nov 13, 2010·Journal of Cellular and Molecular Medicine·Dan-Dan FengYue-Qin Chen
Feb 18, 2011·Journal of Cellular and Molecular Medicine·Chor Sang ChimLi Yu
Apr 29, 2011·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Alvaro J AlencarIzidore S Lossos
Jun 3, 2011·Blood·Santiago Montes-MorenoMiguel A Piris
Jul 29, 2011·Nature·Ryan D MorinMarco A Marra
Sep 2, 2011·RNA Biology·Disa TehlerAnders H Lund
Feb 22, 2012·EMBO Molecular Medicine·Marilena V Iorio, Carlo M Croce
Oct 10, 2012·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Ranjana H AdvaniNathan H Fowler
Feb 15, 2013·Journal of Hematology & Oncology·Kwan-Yeung WongChor-Sang Chim
Mar 7, 2013·International Journal of Hematology·Gustav HedströmGunilla Enblad
Sep 26, 2013·Seminars in Cancer Biology·Carsten U Niemann, Adrian Wiestner
Oct 23, 2013·Proceedings of the National Academy of Sciences of the United States of America·Sukhinder K SandhuCarlo M Croce
Nov 13, 2013·Nature Reviews. Clinical Oncology·Mark RoschewskiWyndham H Wilson
Nov 20, 2013·The Journal of Biological Chemistry·Yarui DiaoZhenguo Wu
Feb 14, 2014·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Yu ShiXiu-Wu Bian
Feb 9, 2016·Experimental Hematology·Sara Correia MarquesKaren Dybkær
May 24, 2016·BioData Mining·Katherine IcaySampsa Hautaniemi

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Datasets Mentioned


Methods Mentioned

reverse transcription PCR
Tandem Repeat

Software Mentioned

DIANA microT
TargetScan Human

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