microRNAs: small molecules with big roles - C. elegans to human cancer

Biology of the Cell
Masaomi Kato, Frank J Slack

Abstract

miRNAs (microRNAs) were first discovered as critical regulators of developmental timing events in Caenorhabditis elegans. Subsequent studies have shown that miRNAs and cellular factors necessary for miRNA biogenesis are conserved in many organisms, suggesting the importance of miRNAs during developmental processes. Indeed, mutations in the miRNA-processing pathway induce pleiotropic defects in development, which accompany perturbation of correct expression of target genes. However, control of gene expression in development is not the only function of miRNAs. Recent work has provided new insights into the role of miRNAs in various biological events, including aging and cancer. C. elegans continues to be helpful in facilitating a further understanding of miRNA function in human diseases.

References

Jul 5, 1991·Science·M HollsteinC C Harris
Aug 1, 1980·Developmental Biology·J E SulstonJ N Thomson
Dec 2, 1993·Nature·C KenyonR Tabtiang
May 1, 1996·Genes & Development·L J Ko, C Prives
Apr 1, 1997·Proceedings of the National Academy of Sciences of the United States of America·S YuD L Garbers
Oct 28, 1998·Proceedings of the National Academy of Sciences of the United States of America·B Lakowski, S Hekimi
Jan 27, 2000·Cell·D Hanahan, R A Weinberg
Aug 3, 2002·Nature Reviews. Neuroscience·Oliver HobertSarah Chang
Apr 4, 2003·Genes & Development·Lee P LimDavid P Bartel
Dec 20, 2003·Nature·Robert J Johnston, Oliver Hobert
Feb 20, 2004·Proceedings of the National Academy of Sciences of the United States of America·George Adrian CalinCarlo M Croce
Mar 16, 2005·Cell·Steven M JohnsonFrank J Slack
May 12, 2005·Current Opinion in Immunology·Victor L J Tybulewicz
Jul 7, 2005·Genes & Development·Benjamin HamiltonSiu Sylvia Lee
Aug 17, 2005·Genes & Development·Meera V Sundaram
Oct 12, 2005·Developmental Dynamics : an Official Publication of the American Association of Anatomists·A Esquela-KerscherF J Slack
Oct 26, 2005·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Betsy R Maller SchulmanFrank J Slack
Mar 1, 2006·Current Opinion in Genetics & Development·Richard W Carthew
Jul 18, 2006·Aging Cell·Carolina Ibáñez-VentosoMonica Driscoll
Jul 28, 2006·Cold Spring Harbor Symposia on Quantitative Biology·P J IaquintaJ A Lees

❮ Previous
Next ❯

Citations

Dec 3, 2009·Breast Cancer Research and Treatment·Reginald M GorczynskiJulia Behnke
Feb 15, 2012·Journal of Mammary Gland Biology and Neoplasia·Suling LiuMax S Wicha
Aug 5, 2009·Clinical Reviews in Allergy & Immunology·Annabelle Grolleau-JuliusRaymond L Yung
Mar 21, 2013·Surgical Oncology·Fangxuan LiShixia Li
Oct 28, 2008·Seminars in Reproductive Medicine·Tannaz ToloubeydokhtiNasser Chegini
Dec 23, 2011·The New England Journal of Medicine·Alireza Heravi-MoussaviDavid G Huntsman
Jan 27, 2009·Proceedings of the National Academy of Sciences of the United States of America·Frank SchembriAvrum Spira
Sep 4, 2010·Antioxidants & Redox Signaling·Subramaniam Ponnappan, Usha Ponnappan
Dec 9, 2008·Bioinformatics·Bogumił KaczkowskiJan Gorodkin
Mar 19, 2009·Carcinogenesis·Muller FabbriGeorge A Calin
Oct 7, 2011·Nucleic Acids Research·Demin DuanJiong Li
Jun 10, 2008·Current Opinion in Hematology·Ramiro Garzon, Carlo M Croce
Mar 23, 2011·Molecular Cancer·Tony Bou KheirLennart Friis-Hansen
Jun 6, 2008·Genome Biology·Stephen E Von Stetina, Susan E Mango
May 28, 2010·PloS One·Nicole Noren HootenMichele K Evans
Apr 7, 2009·BioDrugs : Clinical Immunotherapeutics, Biopharmaceuticals and Gene Therapy·Vivien Wang, Wei Wu
Jul 17, 2010·Regenerative Medicine·Uma LakshmipathyRonald P Hart
Apr 26, 2014·BMC Dermatology·Anne Marie NyholmRobert Gniadecki
Nov 16, 2011·ISRN Surgery·Klaus SteinbrückLúcio F Pacheco-Moreira
Jul 2, 2010·Annual Review of Genomics and Human Genetics·Prue A CowinDavid D L Bowtell
Jan 1, 2010·Journal of Oncology·Li-Hsin ChenWen-Liang Lo
Aug 1, 2008·Nutrition Reviews·Cindy D Davis, Sharon A Ross
Feb 18, 2016·Journal of the Formosan Medical Association = Taiwan Yi Zhi·Chia-Ming LiuCheng-Chia Yu
Apr 17, 2013·Connective Tissue Research·Søren Ohrt-NissenBenny Dahl
Feb 7, 2016·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Rupeng ZhangJuntian Liu
Jul 24, 2014·ACS Applied Materials & Interfaces·Qiao TangWeihong Tan
May 10, 2011·Mutation Research·Catalina PerdomoFrank Schembri
Dec 26, 2009·Experimental Gerontology·Joel LancetaEugenia Wang
Sep 12, 2009·The EMBO Journal·Chin-Hsing LinRobert N Eisenman

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.