MicroRNAs that regulate PTEN as potential biomarkers in colorectal cancer: a systematic review.

Journal of Cancer Research and Clinical Oncology
Jianrong LiuJinrong Zhou

Abstract

MicroRNAs (miRNAs) participate in a variety of biological processes, including tumorigenesis, progression, invasion, and drug resistance to multiple cancers. Phosphatase and tensin homolog (PTEN) is a cancer suppressor gene that has been certified to be regulated by miRNAs in various tumors, including colorectal cancer (CRC). In this review, we screened articles focusing on low PTEN expression in CRC, observed the expression of related miRNAs, analyzed their correlation and relationship with clinicopathological features, and discussed the possibility of these miRNAs as prognostic molecules. We conducted a systematic search for articles published in the Web of Science, PubMed and EBSCO databases between January 1, 2002, and July 18, 2019. We identified these studies by using combinations of the following index entries and key words: 'colorectal tumor OR colorectal neoplasm OR colorectal carcinoma OR colorectal cancer OR CRC', 'protein tyrosine phosphatase OR PTEN', and 'microRNA OR MiRNA OR miRNA OR MicroRNA'. Moreover, we evaluated the underlying association between alterations in PTEN and CRC prognosis. PTEN expression was obviously lower in CRC tissues than in normal mucosa. However, PTEN expression did not differ significant...Continue Reading

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Citations

Nov 17, 2020·Evidence-based Complementary and Alternative Medicine : ECAM·Tong LinLisheng Peng
Feb 5, 2021·Biomedicines·Alessandro ParisiSimona Delle Monache
May 20, 2021·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·Xinyu Lin, Yaohui Wang

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