Microsatellite instability and loss of heterozygosity on chromosome 10 in rat mammary tumors induced by 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine

Molecular Carcinogenesis
M ToyotaM Nagao

Abstract

Microsatellite instability (MI) and loss of heterozygosity (LOH) were examined in mammary tumors induced in Sprague-Dawley x F344 F1 female rats by 2-amino-l-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP). Examination of 62 microsatellite loci revealed MI in nine of 15 (60%) PhIP-induced mammary tumors, and five of these MI-positive tumors had mutations in more than one microsatellite locus. In contrast, two of 12 (17%) 7,12-dimethylbenz[a]anthracene (DMBA)-induced mammary tumors were MI positive but had mutations at only one locus each. Further, by using 37 polymorphic markers specific LOH was observed in four of 15 PhIP induced mammary tumors on distal parts of rat chromosome 10, which is homologous to human chromosome 17q with no background level of LOH. Similarly, DMBA-induced mammary tumors showed specific LOH on the same region of chromosome 10. These data suggest that mismatch-repair deficiency and loss of chromosome 10 are involved in carcinogenesis of PhIP-induced rat mammary tumors.

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Citations

Jan 30, 2004·Oral Oncology·Shanbeh ZienolddinyHiroshi Yamasaki
May 12, 1997·Mutation Research·M NagaoT Sugimura
May 12, 1997·Mutation Research·T Sugimura
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Oct 6, 1997·Proceedings of the National Academy of Sciences of the United States of America·H NakagamaM Nagao
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Oct 16, 2016·Journal of Radiation Research·Kaye ShowlerYoshiya Shimada
Jun 10, 2009·Journal of Radiation Research·Tatsuhiko ImaokaYoshiya Shimada

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