PMID: 8611453Apr 1, 1996Paper

Microsatellite instability in follicle centre cell lymphoma

British Journal of Haematology
J RandersonG J Morgan

Abstract

Fluorescent polymerase chain reaction (PCR) was used to assay 12 microsatellite markers (APC x 2, DCC, P53 x 2, RB1, NM23, WT1, D6S260, D6S262, D6S281 and TNFa) to look for evidence of microsatellite instability in 40 cases of follicle centre cell lymphoma (FCC). Evidence of novel alleles seen in the tumour tissue but not the normal uninvolved tissue was seen in seven cases (17%). In only two of these cases (5%) was more than one locus involved but in these cases multiple affected loci were seen (4/12 and 7/12 respectively). The detection of microsatellite instability indicates a DNA repair defect such as that which would be predicted to occur in cells with mutated mismatch repair genes, a novel finding in FCC lymphoma.

Citations

Jun 4, 1998·International Journal of Cancer. Journal International Du Cancer·W S XuG Srivastava
Jan 15, 1999·Pathology Oncology Research : POR·R Naidoo, R Chetty
May 10, 2002·Leukemia & Lymphoma·Vassiliki KotoulaConstantine S Papadimitriou
Jan 8, 2008·Leukemia Research·Kaname MiyashitaNaokuni Uike
Jan 12, 1999·Experimental Cell Research·N Claij, H te Riele
Apr 7, 2005·British Journal of Cancer·E NivM Lishner
May 29, 2000·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·C RostyP Laurent-Puig
Jan 21, 2000·The Journal of Pathology·S A Burchill, P J Selby

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