PMID: 9439149Jun 1, 1997Paper

Microsatellite instability in Korean patients with gastric adenocarcinoma

The Korean Journal of Internal Medicine
M S JeeC M Yoon

Abstract

Microsatellites are short repeated oligonucleotide sequences found throughout the human genome. High mutation rates in microsatellite sequences have been found in tumors from patients with hereditary non-polyposis colorectal carcinoma and some sporadic carcinomas. However, little information is available regarding RER-positive phenotype in gastric carcinomas, particularly in terms of age of onset and other pathologic features, such as histologic types, degree of differentiation, location or stage of the carcinoma. To obtain a better understanding of the molecular mechanism of gastric carcinogenesis, microsatellite instability was examined at 6 gene loci (D2S71, D2S119, D3S1067, D6S87, D8S87, D11S905) in 77 gastric carcinomas (40 cases of young patients and 37 cases of elderly patients). RER-positive phenotypes were found in 17 (22.1%) of 77 cases. In young patients (under 40 years) RER-positive phenotype was found in 9 (22.5%) of 40 cases, and in elderly patients 8 (21.6%) of 37 cases. Moderately differentiated carcinoma revealed a significantly high frequency of RER-positive phenotype than well differentiated carcinoma(p < 0.001). Tumors arising from the middle third (p < 0.001) or lower third (p < 0.001) revealed higher frequ...Continue Reading

References

Oct 29, 1992·Nature·J WeissenbachM Lathrop
Mar 11, 1991·Nucleic Acids Research·S A JordanP Humphries
Aug 11, 1990·Nucleic Acids Research·J L WeberP E May
Nov 1, 1988·Annals of Surgery·P J MatleyS K Price
Apr 1, 1988·Scandinavian Journal of Gastroenterology·J P MecklinI Saario
Apr 1, 1987·Cancer·P L TsoI Cohn
Feb 1, 1994·Nature Genetics·R WoosterO D Wiestler
Jan 1, 1993·Journal of Cancer Research and Clinical Oncology·E Tahara
May 7, 1993·Science·L A AaltonenS R Hamilton
May 7, 1993·Science·S N ThibodeauD Schaid

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