PMID: 9641458Jun 26, 1998Paper

Microsatellite instability in sarcomas

Annals of Surgical Oncology
S S MartinH S Schwartz

Abstract

Microsatellite instability (MIN) has been studied in a variety of carcinomas and gynecologic sarcomas, but never in musculoskeletal sarcomas. We evaluated 16 skeletal and soft tissue sarcomas at nine genetic loci from chromosomal regions 1q, 5q, 7q, 12p, 13q, 17p, 19q, and two at 11p--all potential regions of interest regarding musculoskeletal sarcomas. MIN was identified at one or more loci in seven of the cancers studied (44%). Three tumors had more than one locus with MIN and one tumor, a high-grade osteogenic sarcoma, had five of nine loci positive for MIN. These results indicate that musculoskeletal sarcomas show instability in areas inside and outside the loci of known oncogenes. Areas of mismatch repair, as heralded by MIN, may contribute to the vast heterogeneity of these neoplasms.

References

May 14, 1992·The New England Journal of Medicine·J ToguchidaM S Sasaki
Sep 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·M F HansenW K Cavenee
Feb 1, 1994·Genes, Chromosomes & Cancer·W A HoogerwerfC A Griffin
Dec 23, 1994·Science·P Modrich
Mar 17, 1994·The New England Journal of Medicine·B L Gallie
Feb 1, 1994·Nature Genetics·R WoosterO D Wiestler
May 7, 1993·Science·S N ThibodeauD Schaid
Jan 1, 1996·CA: a Cancer Journal for Clinicians·S L ParkerP A Wingo
Nov 1, 1995·Genes, Chromosomes & Cancer·P HackmanB Lambert
Jan 1, 1996·Cancer Genetics and Cytogenetics·M G ButlerH S Schwartz
May 1, 1996·Cancer Genetics and Cytogenetics·M ScheinerM G Butler
Jul 17, 1998·Cancer Genetics and Cytogenetics·V R TalwalkarH S Schwartz

❮ Previous
Next ❯

Citations

Feb 13, 2013·ISRN Oncology·Michael J MonumentRl Tx Randall
Mar 1, 2000·Journal of Surgical Oncology·L KlinglerH S Schwartz
Dec 20, 2008·Virchows Archiv : an International Journal of Pathology·Achim WeberC James Kirkpatrick
Apr 19, 2006·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Joaquin J GarciaAndrew E Horvai

❮ Previous
Next ❯

Related Concepts

Related Feeds

Carcinosarcoma

Carcinosarcoma is a malignant neoplasm that contains elements of carcinoma and sarcoma so extensively intermixed as to indicate neoplasia of epithelial and mesenchymal tissue. Discover the latest research on carcinosarcoma here.

Related Papers

La Chirurgia degli organi di movimento
J S WunderA A Czitrom
Current Opinion in Oncology
Cancer Chemotherapy and Biological Response Modifiers
J Verweij
Current Opinion in Oncology
© 2022 Meta ULC. All rights reserved