Microsatellite instability in sporadic colon carcinomas has no independent prognostic value in a Belgian study population

European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)
Vanessa DeschoolmeesterMarc Peeters

Abstract

Pathological stage is currently the most important determinant of colorectal cancer prognosis. Hence, identification of additional prognostic markers is warranted. This study aimed to analyse the prognostic relevance of microsatellite instability (MSI) in 241 colon and 90 rectal tumours, using a mononucleotide loci multiplex PCR assay and immunohistochemistry. Thirty (12.4%) colon tumours and one rectal tumour showed MSI. Although MSI was associated with proximal location and poor differentiation, no survival benefit was observed. The prognostic value of stage and differentiation was confirmed in this study. Analysis by stage revealed a longer overall (stage II/III) and disease free survival (stage II) for patients with well differentiated tumours. In addition, age and distal localisation were related to longer overall survival in stage II tumours. In conclusion, our findings show an association of MSI in sporadic colon tumours and certain clinical features; however, they do not suggest a survival benefit for MSI tumours.

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Citations

Nov 15, 2011·International Journal of Colorectal Disease·Chun-Chi LinShih-Ching Chang
Apr 14, 2010·BMC Immunology·Vanessa DeschoolmeesterJan B Vermorken
Jun 30, 2010·The Oncologist·Vanessa DeschoolmeesterJan B Vermorken
Nov 18, 2015·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Masashi YahagiYuko Kitagawa
Sep 28, 2010·Journal of Surgical Oncology·Jung Wook HuhYoung Jin Kim

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