PMID: 108379Apr 1, 1979

Microscopic changes in rat tongue following experimental cryosurgery

Journal of Oral Pathology
B BuchM Shear


Histological changes were studied in the rat tongue for varying periods of time up to 14 days following the application of a cryoprobe to the dorsal surface of rat tongue. Within minutes of the application, focal subepithelial vesiculation and hyperemia occurred. At 3 h there was evidence of damage to capillary walls, resulting in hemorrhage. Arterioles and venules were thrombosed and there were degenerative changes in the muscle layer of their walls. At 6 h ventral epithelium showed evidence of damage. At this stage vessel walls were pavemented with neutrophilic polymorphonuclear leukocytes (PMN) and some of the latter were seen in the vessel walls. At 24 h abundant PMN, many of them necrotic, were present in the vessel walls, apparently unable to pass through them. At 48 h numerous PMN were seen adhering to degenerating muscle fibers. By 4 days necrotic changes extended through the full thickness of the tongue, but concurrently it was observed that the larger thrombosed vessels were becoming recanalized. At 5 days repair by granulation tissue was taking place and at 6 days the vasculature was virtually reconstituted. By 14 days healing was complete.


Sep 1, 1976·Oral Surgery, Oral Medicine, and Oral Pathology·J P Shepherd
Oct 1, 1974·American Journal of Surgery·A W Weaver, D B Smith
Mar 1, 1972·Journal of Periodontology·W C HurtG G Rose
Jun 1, 1972·Cryobiology·G G Litvan
Oct 1, 1965·Archives of Environmental Health·J P Kulka
Jan 1, 1964·The Journal of Surgical Research·R C WEATHERLEY-WHITEB C PATON


Mar 1, 1981·The British Journal of Oral Surgery·D G MacDonald, O A Pospisil
Mar 1, 1993·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·M A Pogrel
Feb 1, 1982·International Journal of Oral Surgery·H TalJ Lemmer
Jun 1, 1985·Cryobiology·B D Burhan, D K Whittaker
Oct 1, 1985·Cryobiology·D K Whittaker, B D Burhan
Jul 1, 1980·Journal of Oral Pathology·D K Whittaker
Apr 1, 1991·International Journal of Oral and Maxillofacial Surgery·T B Kardos, M M Ferguson
Apr 1, 1989·International Journal of Oral and Maxillofacial Surgery·R SchmelzeisenS Hessel
Oct 1, 1986·The Journal of the American Dental Association·H Tal, B Rifkin

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