Microscopic colitis and Medication Use.

Clinical Medicine Insights. Gastroenterology
Monina F PascuaJames D Lewis

Abstract

BACKGROUND: The incidence of microscopic colitis (MC) is increasing, but its etiology remains unknown. Case reports and limited controlled data suggest that commonly prescribed drugs may be triggers. The aim of this study was to evaluate the prevalence of selected medication use [Proton pump inhibitors (PPIs), HMG-CoA reductase inhibitors (statins), and Selective serotonin reuptake inhibitors (SSRIs)] in patients with MC compared to 'random controls' and 'diarrhea controls.' METHODS: All patients were selected from primary care practices of a university health system during 2002 to 2007. Patients with biopsy proven lymphocytic or collagenous colitis were identified as cases. Diarrhea controls consisted of a 10:1 random sample of patients with chronic diarrhea and normal colon biopsies. Ten random controls were matched to each case on sex and index date (date of biopsy proven diagnosis). Drugs prescribed within the year prior to the index date were collected from the electronic medical record system. RESULTS: 26 cases (median age 68.9 yrs), 259 random, and 259 diarrhea controls were identified. The adjusted ORs for PPI, SSRI, and statin prescription within 12 months of diagnosis of MC between cases and diarrhea controls were 0.2...Continue Reading

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Citations

Feb 22, 2012·Nature Reviews. Gastroenterology & Hepatology·Runjan Chetty, Dhirendra Govender
Jun 19, 2012·Journal of Crohn's & Colitis·A MünchUNKNOWN European Microscopic Colitis Group (EMCG)
Dec 4, 2012·Micron : the International Research and Review Journal for Microscopy·Vahid MalekianMahdie Rezaeian
Jan 28, 2015·The American Journal of Gastroenterology·Jinlu TongZhihua Ran
Oct 14, 2016·The Annals of Pharmacotherapy·Ernest H LawTodd A Lee
Apr 12, 2017·Journal of Clinical Pharmacology·Michelle PearlmanIshak A Mansi
Aug 26, 2014·Inflammatory Bowel Diseases·Ole K BonderupGunnar L Nielsen
May 28, 2019·Journal of Crohn's & Colitis·Harry D GreenMichael N Weedon
May 23, 2020·Clinical and Experimental Gastroenterology·Matt DavieAnastasios Koulaouzidis
Nov 26, 2015·Alimentary Pharmacology & Therapeutics·F Fernández-BañaresUNKNOWN Spanish Microscopic Colitis Group (SMCG)
May 25, 2021·Alimentary Pharmacology & Therapeutics·Yamini Yadav, Nicholas J Talley
Aug 1, 2021·Alimentary Pharmacology & Therapeutics·Yuanbin Liu, Mingkai Chen

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Methods Mentioned

BETA
biopsy
biopsies

Software Mentioned

STATIN

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