Microscopic colitis in Denmark and Sweden: incidence, putative risk factors, histological assessment and endoscopic activity

Scandinavian Journal of Gastroenterology
Sanna DavidsonLars Kristian Munck

Abstract

The significantly higher incidence rates of microscopic colitis (MC) in Denmark compared to Sweden remains unexplained. Consecutive patients with newly diagnosed MC in the neighbouring regions of Skåne in 2011-2015 and Zealand in 2010-2016 were prospectively identified. Data on large bowel endoscopies and biopsies rates were retrieved. Information on putative factors were obtained from registers and literature. Interobserver agreement between pathologists from both regions on 40 blinded hematoxylin and eosin (H&E)-stained colon biopsies (collagenous colitis (CC), lymphocytic colitis (LC), non-specific inflammation and normal) was evaluated using kappa statistics. The mean annual incidence per 105 inhabitants in Skåne and Zealand 2010-2015 was 5.9 (95% CI 4.6-7.3) versus 16.4 (95% confidence intervals (95% CI) 13.6-19.2) for CC and 2.7 (95% CI 1.0-4.3) versus 11.1 (95% CI 8.8-13.4) for LC, respectively. Number of endoscopies with biopsy per 1000 and the rate of MC per endoscopy with biopsy was higher in Zealand (34-52/1000) than in Skåne (12-21/1000). The kappa value for overall agreement between pathologists was good (0.72; 95% CI 0.64-0.79). Prescription of proton pump inhibitors and selective serotonin reuptake inhibitors was...Continue Reading

References

Mar 20, 2002·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·I WeileP A Krasilnikoff
Jun 12, 2009·Journal of Pediatric Gastroenterology and Nutrition·Anna MyléusAnnelie Carlsson
Aug 23, 2011·Scandinavian Journal of Gastroenterology·Lina VigrenHenrik Hjortswang
Oct 5, 2011·Alimentary Pharmacology & Therapeutics·C BjørnbakL K Munck
Jun 22, 2012·World Journal of Gastroenterology : WJG·Lina VigrenKlas Sjöberg
Feb 20, 2013·Pediatrics·Anneli IvarssonAnnelie Carlsson
Apr 5, 2013·Inflammatory Bowel Diseases·Fernando Fernández-BañaresUNKNOWN RECOMINA Project, GETECCU (Grupo Español de Enfermedades de Crohn y Colitis Ulcerosa)
Jun 27, 2013·Scandinavian Journal of Gastroenterology·Lina VigrenKlas Sjöberg
Jul 23, 2013·Journal of Crohn's & Colitis·F MagroUNKNOWN European Crohn's and Colitis Organisation (ECCO)
Sep 14, 2013·Human Pathology·Anne-Marie Kanstrup FiehnLars Kristian Munck
Oct 15, 2013·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Nicole M GentileDarrell S Pardi
Jan 11, 2014·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Andreas Münch, Cord Langner
Aug 26, 2014·Inflammatory Bowel Diseases·Ole K BonderupGunnar L Nielsen
Dec 3, 2014·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·Bas P M VerhaeghMarieke J Pierik
Jan 28, 2015·The American Journal of Gastroenterology·Jinlu TongZhihua Ran
Feb 18, 2015·Scandinavian Journal of Gastroenterology·Anna HorwitzAllan Linneberg
Nov 2, 2015·Journal of Crohn's & Colitis·Julie RasmussenLars Kristian Munck
Dec 19, 2015·Scandinavian Journal of Gastroenterology·Marie-Rose MellanderJan Björk
Mar 10, 2016·Alimentary Pharmacology & Therapeutics·B P M VerhaeghD M A E Jonkers
Nov 3, 2016·European Journal of Clinical Nutrition·J K LarssonK Sjöberg
Mar 30, 2017·European Journal of Gastroenterology & Hepatology·Anna WickbomCurt Tysk
May 5, 2017·Inflammatory Bowel Diseases·Bas P M VerhaeghDaisy M A E Jonkers
Jun 1, 2017·Nordisk alkohol- & narkotikatidskrift : NAT·Matilda Hellman, Tom Kettunen

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Citations

Jun 28, 2019·Alimentary Pharmacology & Therapeutics·Danila GuagnozziLuca Pastorelli
Jun 26, 2020·Alimentary Pharmacology & Therapeutics·Nynne Nyboe AndersenSigne Wildt
Jan 13, 2021·Journal of Crohn's & Colitis·Bas P M VerhaeghLars K Munck
Jun 12, 2021·Nature Reviews. Disease Primers·Kristin E BurkeHamed Khalili
Jul 4, 2021·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·June TomeDarrell S Pardi
Nov 7, 2020·Journal of Crohn's & Colitis·Lars Kristian Munck
Aug 21, 2021·United European Gastroenterology Journal·Andreas MünchLars Kristian Munck
Oct 16, 2021·Alimentary Pharmacology & Therapeutics·Signe WildtNynne Nyboe Andersen

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