Microscopic colitis with granulomatous inflammation

Histopathology
T J SaurineR P Eckstein

Abstract

To present four cases in which the clinical and endoscopic findings were consistent with microscopic colitis, but the inflammatory infiltrate included a conspicuous granulomatous reaction. Microscopic colitis is defined as a syndrome of chronic watery diarrhoea with a chronic inflammatory cell infiltrate in the colonic mucosa and without significant abnormalities at colonoscopy. It encompasses both collagenous and lymphocytic colitis. In all cases the clinical course and endoscopic findings were unlike Crohn's disease and no infectious agents were identified. In all cases the main symptom was frequent watery diarrhoea, all were female and there were no endoscopic findings apart from mild mucosal erythema. Histologically, an active chronic inflammatory infiltrate was accompanied by scattered non-necrotizing granulomas, often closely associated with crypt epithelium (cryptolytic or pericryptal granulomas). In three of the patients the symptoms began after antibiotic use or had worsened with antibiotic use. Two of the patients were on allopurinol at the time of the onset of symptoms. In two of the patients symptoms have continued for more than 10 years. One patient died as a result of medical complications relating to severe diarr...Continue Reading

References

Jun 1, 1991·Human Pathology·M MarazuelaJ A Vargas
Feb 1, 1990·Digestive Diseases and Sciences·F M GiardielloJ H Yardley
Jun 1, 1995·Gut·B VeressL Bergman
Jan 1, 1994·Virchows Archiv : an International Journal of Pathology·W V Bogomoletz
Feb 1, 1997·Journal of Clinical Pathology·F D LeeR I Russell
Feb 14, 1998·Journal of Clinical Pathology·B F WarrenG T Williams
Apr 25, 2000·Journal of Clinical Gastroenterology·W J Tremaine
Dec 23, 2000·Canadian Journal of Gastroenterology = Journal Canadien De Gastroenterologie·J BohrG Järnerot
Apr 12, 2002·Histopathology·L LibbrechtK Geboes

❮ Previous
Next ❯

Citations

Feb 22, 2012·Nature Reviews. Gastroenterology & Hepatology·Runjan Chetty, Dhirendra Govender
Sep 20, 2007·Internal Medicine·Hiroki IwaiToshifumi Hibi
Dec 26, 2008·World Journal of Gastroenterology : WJG·Curt TyskSune Eriksson
Aug 2, 2012·Archives of Pathology & Laboratory Medicine·Lisa A Cerilli, Joel K Greenson
Aug 13, 2005·Advances in Anatomic Pathology·Fuju ChangCharles Vu
Aug 25, 2009·Advances in Anatomic Pathology·Susanne W CarmackRobert M Genta
Oct 17, 2015·Expert Review of Gastroenterology & Hepatology·Aranzazu Jauregui-AmezagaKarel Geboes
Aug 25, 2012·Gastroenterology Clinics of North America·Cord Langner
Feb 18, 2011·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·Vincenzo VillanacciGabrio Bassotti
May 16, 2006·Alimentary Pharmacology & Therapeutics·N NyhlinC Tysk
Dec 6, 2005·Histopathology·D Sandmeier, H Bouzourene
Jan 13, 2006·Histopathology·R K Yantiss, R D Odze
Jan 7, 2015·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Robert D Odze
Feb 28, 2007·The American Journal of Gastroenterology·Rhonda K Yantiss, Robert D Odze
Jul 10, 2014·International Journal of Surgical Pathology·Giovanni De Petris, Longwen Chen

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.