Microscopic polyangiitis: Clinical presentation

Autoimmunity Reviews
Peter M Villiger, Loïc Guillevin

Abstract

Microscopic polyangiitis (MPA) is a member of the family of ANCA-associated vasculitides. Its characteristic histology shows a necrotizing small vessel vasculitis with little or absent immune deposits (pauci-immune vasculitis). In Western countries MPA shows a lower prevalence than Wegener's disease, it affects more men than women and commences at the age of > or = 50 years. The two organs most typically involved and often defining prognosis are the kidneys and the lungs. MPA may concomitantly or sequentially involve other organs such as the nervous system, the skin, the musculoskeletal system, but also the heart, the eye and the intestines. Treatment decisions should be based on severity and pattern of organ involvement and respect the five factor score (FFS). Life- or organ- threatening disease is treated with glucocorticoids and (pulse) cyclophosphamide. Plasmapheresis and i.v.immunoglobulins have been shown to be beneficial as additional measure in severe cases. If renal function is preserved, Methotrexate may be considered to induce remission, and if the FFS equals 0, remission may be induced with glucocorticoid monotherapy. Maintenance therapy is recommended with Azathioprin, mycophenolate mofetil may be used as a second ...Continue Reading

References

Mar 15, 1992·Annals of Internal Medicine·G S HoffmanA S Fauci
Oct 1, 1991·Kidney International·C D PuseyC M Lockwood
Jun 1, 1997·QJM : Monthly Journal of the Association of Physicians·D AduP A Bacon
Mar 24, 1999·Arthritis and Rheumatism·L GuillevinB Jarrousse
Jun 30, 2000·QJM : Monthly Journal of the Association of Physicians·D R JayneC M Lockwood
Jan 13, 2001·Annals of the Rheumatic Diseases·R A WattsD G Scott
Jul 4, 2003·The New England Journal of Medicine·David JayneUNKNOWN European Vasculitis Study Group
Mar 27, 2004·Clinical Rheumatology·Julio A ChirinosDaniel M Lichtstein
Aug 19, 2004·Rheumatology·T PankhurstL Harper
Aug 10, 2005·Seminars in Respiratory and Critical Care Medicine·Richard A Watts, David G I Scott
Oct 25, 2006·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Joseph G ParambilJay H Ryu
Jun 22, 2007·Journal of the American Society of Nephrology : JASN·David R W JayneUNKNOWN European Vasculitis Study Group
Jun 27, 2007·Clinical and Experimental Nephrology·Jorge A LamarcheCraig Courville
Nov 22, 2007·The American Journal of the Medical Sciences·Akinori HaraShuichi Kaneko
Dec 1, 2007·Arthritis and Rheumatism·Olivier FainLoïc Guillevin
Dec 11, 2007·Rheumatology International·Shiro NiiyamaKensei Katsuoka
Apr 29, 2008·Arthritis and Rheumatism·Corneliu HenegarUNKNOWN French Vasculitis Study Group
Jun 21, 2008·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Richard A WattsHiroshi Hashimoto
Jul 24, 2008·The British Journal of Dermatology·N KlugerUNKNOWN French Vasculitis Study Group
Oct 30, 2008·Annals of the Rheumatic Diseases·B HervierUNKNOWN French Vasculitis Study Group
Dec 26, 2008·The New England Journal of Medicine·Christian PagnouxUNKNOWN French Vasculitis Study Group
Nov 21, 2009·The European Respiratory Journal·G E TzelepisH M Moutsopoulos
Nov 26, 2009·The Annals of Thoracic Surgery·Masaaki RyomotoHiroyuki Hao
May 18, 2010·Autoimmunity Reviews·Richard W Lee, David P D'Cruz
Jul 14, 2010·Autoimmunity Reviews·Christian PowellM Eric Gershwin

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Citations

Dec 29, 2013·Current Allergy and Asthma Reports·Monica BhagatMildred Kwan
Jul 26, 2013·AJR. American Journal of Roentgenology·Stefan Franz NemecAlexander A Bankier
Aug 28, 2012·Autoimmunity Reviews·Renato A SinicoAntonella Radice
Sep 11, 2012·Autoimmunity Reviews·Angelo V MarzanoEmilio Berti
Dec 2, 2015·Experimental and Therapeutic Medicine·Ran WangGeng-Yun Sun
May 7, 2013·Neurologic Clinics·Michael P CollinsJohn T Kissel
Dec 12, 2012·Autoimmunity Reviews·Antonello Pani
Jun 12, 2012·Archivos de bronconeumología·Natalia Martín-Suñé, Juan José Ríos-Blanco
Nov 26, 2011·Reumatología clinica·Beatriz Zazueta Montiel, Luis Felipe Flores Suárez
Feb 13, 2016·The Korean Journal of Internal Medicine·A Young ChoIn O Sun
Aug 16, 2015·Cardiovascular Pathology : the Official Journal of the Society for Cardiovascular Pathology·Sari IwasakiAkihiro Ishizu
Apr 22, 2015·Revue des maladies respiratoires·A ParrotJ Cadranel
Dec 18, 2013·Lancet Neurology·Kelly Graham GwathmeyP James Bonham Dyck
Oct 15, 2013·Autoimmunity Reviews·Michael SoussanArsène Mekinian
Nov 17, 2012·The Journal of Allergy and Clinical Immunology·Sabine AdlerPeter M Villiger
Jun 9, 2016·International Urology and Nephrology·Manish RathiAman Sharma
Oct 25, 2016·Autoimmunity Reviews·Francesca BruniniCharles D Pusey
Aug 11, 2012·Therapeutic Advances in Respiratory Disease·Zulma X YuntKevin K Brown
Feb 24, 2016·World Journal of Gastroenterology : WJG·Tomoya IidaKiyoshi Kasai
Jun 4, 2017·Indian Journal of Pediatrics·Rakesh Kumar PilaniaMeenu Singh
Mar 5, 2020·Saudi Journal of Kidney Diseases and Transplantation : an Official Publication of the Saudi Center for Organ Transplantation, Saudi Arabia·Hela JebaliMohamed Karim Zouaghi
Aug 12, 2019·Rheumatology International·Fabian LötscherIna Kötter
Mar 4, 2021·BMJ Case Reports·Jennifer Jane GileMichael R Mueller
Mar 16, 2021·Frontiers in Medicine·Filippo FagniGiacomo Emmi
Sep 1, 2018·Seminars in Arthritis and Rheumatism·Anaïs DartevelLuc Mouthon
Oct 2, 2019·Journal of Autoimmunity·Thibault MailletUNKNOWN French Vasculitis Study Group (FVSG)
Jul 1, 2021·Curēus·Nishant AllenaBoris Medvedovsky
Aug 31, 2021·Clinical Reviews in Allergy & Immunology·Marco FolciEnrico Brunetta
Sep 10, 2021·International Journal of Rheumatic Diseases·Hannah Hu, Karuna Keat

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