PMID: 3766122Jan 1, 1986Paper

Microscopical and ultrastructural investigations on the development of the blood-brain barrier in the chick embryo optic tectum

Acta Neuropathologica
L RoncaliL Mancini

Abstract

The formation of a blood-brain barrier to horseradish peroxidase was microscopically and ultrastructurally investigated in the tectum opticum of the chick during development of the intraneural blood vessel network from the 6th incubation day to hatching, and in adult specimens. Extravasation of the circulating marker, apparently unimpeded during early stages of vasculogenesis, starts to diminish from the 14th incubation day (i.d.) and is prevented after the 18th i.d. The tracer seems to get out of the vessel lumina through the sites of reciprocal contact between adjacent endothelial cells, and the differentiation of tight junctions there hinders the passage of peroxidase particles. The formation of numerous endothelial vacuoles during early vasculogenesis and the setting of the blood-brain barrier are discussed in connection with the mechanisms of transendothelial transport, and respectively, the processes of moulding of the growing endothelia.

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Citations

Jan 1, 1987·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·F Joó
Aug 4, 2004·Neurotoxicology·M BertossiL Roncali
May 13, 1999·Brain Research. Developmental Brain Research·B NicoL Roncali
Feb 17, 2000·Brain Research. Developmental Brain Research·B NicoL Roncali
Jan 1, 1988·Progress in Histochemistry and Cytochemistry·A W Vorbrodt
Feb 1, 1993·Annals of Anatomy = Anatomischer Anzeiger : Official Organ of the Anatomische Gesellschaft·D RibattiM Bertossi
Jan 8, 2015·Frontiers in Neuroscience·Norman R SaundersHans-Christian Bauer
Mar 17, 2007·Journal of Environmental Science and Health. Part A, Toxic/hazardous Substances & Environmental Engineering·Zofia E Gagnon, Amit Patel
Jan 27, 2006·The Anatomical Record. Part B, the New Anatomist·Domenico RibattiMarco Artico
Jul 28, 2013·Journal of the Indian Society of Pedodontics and Preventive Dentistry·P H ShilpaN C Kumar
Oct 16, 1992·Pharmaceutisch Weekblad. Scientific Edition·J B Van BreeD D Breimer

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