PMID: 6498133Nov 1, 1984

Microscopical studies of necrotising scleritis. II. Collagen degradation in the scleral stroma

The British Journal of Ophthalmology
R D Young, P G Watson

Abstract

Electron microscopy of tissue excised during surgery in eight cases of advanced anterior necrotising scleritis showed degradation of collagen in the scleral stroma by both intracellular and extracellular mechanisms. In the first of these mechanisms cells resembling active fibroblasts and macrophages were observed in the process of phagocytosis of collagen fibrils into vacuoles associated with dense cytoplasmic granules. In the second mechanism collagen fibrils in large areas of the scleral stroma appeared swollen and unravelled, or completely solubilised, without close association with stromal cells. Both activation and degeneration of stromal fibrocytes were evident in zones of extracellular fibril degradation. These changes appeared to take place prior to invasion of the stroma by cells of the granuloma.

References

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Mar 1, 1977·Arthritis and Rheumatism·E D HarrisA H Murley
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Nov 1, 1984·The British Journal of Ophthalmology·R D Young, P G Watson
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Citations

Apr 27, 2004·Experimental Eye Research·P G Watson, Robert D Young
Mar 21, 1998·Ophthalmology·A HeiligenhausK P Steuhl
Jan 1, 1988·Eye·C M CalthorpeA C McCartney
Mar 31, 2007·Nature Clinical Practice. Rheumatology·Justine R SmithJames T Rosenbaum
Nov 1, 1984·The British Journal of Ophthalmology·R D Young, P G Watson
Nov 15, 1993·American Journal of Ophthalmology·C J PavlinF S Foster
Mar 1, 1988·Survey of Ophthalmology·W E Benson
Jun 9, 2016·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Anett KarlMike Francke
Jun 7, 2020·Experimental Eye Research·D P C VergouwenM W J Schreurs

Related Concepts

Zyderm
Inflammation
Electron Microscopy
Necrosis
Neutrophil Band Cells
Phagocytes
Sclera

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