PMID: 6498133Nov 1, 1984

Microscopical studies of necrotising scleritis. II. Collagen degradation in the scleral stroma

The British Journal of Ophthalmology
R D Young, P G Watson


Electron microscopy of tissue excised during surgery in eight cases of advanced anterior necrotising scleritis showed degradation of collagen in the scleral stroma by both intracellular and extracellular mechanisms. In the first of these mechanisms cells resembling active fibroblasts and macrophages were observed in the process of phagocytosis of collagen fibrils into vacuoles associated with dense cytoplasmic granules. In the second mechanism collagen fibrils in large areas of the scleral stroma appeared swollen and unravelled, or completely solubilised, without close association with stromal cells. Both activation and degeneration of stromal fibrocytes were evident in zones of extracellular fibril degradation. These changes appeared to take place prior to invasion of the stroma by cells of the granuloma.


Sep 1, 1975·The British Journal of Nutrition·A PirieM C Burleigh
May 5, 1975·Biochimica Et Biophysica Acta·A Pardo, R P Tamayo
Mar 1, 1977·Arthritis and Rheumatism·E D HarrisA H Murley
Nov 1, 1969·Journal of Ultrastructure Research·P F Parakkal
Jun 1, 1968·The British Journal of Ophthalmology·D Sevel
Dec 1, 1967·American Journal of Ophthalmology·D Sevel
Nov 1, 1981·Journal of Periodontal Research·D W PettigrewD M Brunette
Jan 1, 1983·Nephron·G ZavagliA Farinelli
Nov 1, 1984·The British Journal of Ophthalmology·R D Young, P G Watson
Oct 1, 1983·The Journal of Investigative Dermatology·W T McGaw, A R Ten Cate
Jul 1, 1952·The British Journal of Ophthalmology·N ASHTON, H E HOBBS


Apr 27, 2004·Experimental Eye Research·P G Watson, Robert D Young
Mar 21, 1998·Ophthalmology·A HeiligenhausK P Steuhl
Jan 1, 1988·Eye·C M CalthorpeA C McCartney
Mar 31, 2007·Nature Clinical Practice. Rheumatology·Justine R SmithJames T Rosenbaum
Nov 1, 1984·The British Journal of Ophthalmology·R D Young, P G Watson
Nov 15, 1993·American Journal of Ophthalmology·C J PavlinF S Foster
Mar 1, 1988·Survey of Ophthalmology·W E Benson
Jun 9, 2016·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Anett KarlMike Francke
Jun 7, 2020·Experimental Eye Research·D P C VergouwenM W J Schreurs

Related Concepts

Electron Microscopy
Neutrophil Band Cells

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Alzheimer's Disease: MS4A

Variants within the membrane-spanning 4-domains subfamily A (MS4A) gene cluster have recently been implicated in Alzheimer's disease in genome-wide association studies. Here is the latest research on Alzheimer's disease and MS4A.

Pediculosis pubis

Pediculosis pubis is a disease caused by a parasitic insect known as Pthirus pubis, which infests human pubic hair, as well as other areas with hair including eye lashes. Here is the latest research.

Rh Isoimmunization

Rh isoimmunization is a potentially preventable condition that occasionally is associated with significant perinatal morbidity or mortality. Discover the latest research on Rh Isoimmunization here.

Genetic Screens in iPSC-derived Brain Cells

Genetic screening is a critical tool that can be employed to define and understand gene function and interaction. This feed focuses on genetic screens conducted using induced pluripotent stem cell (iPSC)-derived brain cells. It also follows CRISPR-Cas9 approaches to generating genetic mutants as a means of understanding the effect of genetics on phenotype.

Enzyme Evolution

This feed focuses on molecular models of enzyme evolution and new approaches (such as adaptive laboratory evolution) to metabolic engineering of microorganisms. Here is the latest research.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Pharmacology of Proteinopathies

This feed focuses on the pharmacology of proteinopathies - diseases in which proteins abnormally aggregate (i.e. Alzheimer’s, Parkinson’s, etc.). Discover the latest research in this field with this feed.

Alignment-free Sequence Analysis Tools

Alignment-free sequence analyses have been applied to problems ranging from whole-genome phylogeny to the classification of protein families, identification of horizontally transferred genes, and detection of recombined sequences. Here is the latest research.