Microscopically positive surgical margins and local recurrence in thyroid cancer. A meta-analysis

European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology
Alvaro SanabriaIain Nixon

Abstract

Microscopically positive surgical margins are a prognostic factor of recurrence in advanced thyroid carcinoma. However, information on early and completely resected thyroid tumors is scarce. Some studies do not identify any association between positive margin and local recurrence. The objective of this study was to perform a meta-analysis to measure the association of microscopically positive surgical margins and local recurrence in patients who underwent total thyroidectomy. Clinical trials assessing the association between microscopically positive surgical margin and local recurrence in patients with early-stage, well-differentiated thyroid carcinoma who underwent total thyroidectomy were evaluated. The outcome measured was local recurrence in the thyroid bed. A systematic review and meta-analysis was done using a random-effects model. Six studies with 7696 patients were identified. Methodological quality was good, and we did not identify statistical heterogeneity or publication bias. The risk difference for microscopically positive surgical margin and local recurrence was 0% (95% CI 0 to 1). Meta-analysis did not find a statistically significant association between microscopically positive surgical margin and local recurrenc...Continue Reading

Citations

Feb 9, 2021·Langenbeck's Archives of Surgery·Alvaro SanabriaRicard Simo
Nov 7, 2020·Medicina·Noor AddasiWhitney Goldner

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