May 25, 2002

Microsphaerones A and B, two novel gamma-pyrone derivatives from the sponge-derived fungus Microsphaeropsis sp

Journal of Natural Products
Chang-Yun WangRainer Ebel

Abstract

Two new metabolites, microsphaerones A (1) and B (2), were identified from the EtOAc extract of the culture of an undescribed fungus of the genus Microsphaeropsis, isolated from the Mediterranean sponge Aplysina aerophoba. Compounds 1 and 2 represent the first examples of gamma-pyrone derivatives of the fungal genus Microsphaeropsis. The structures of the compounds were elucidated on the basis of comprehensive spectral analysis ((1)H, (13)C, (1)H-(1)H COSY, HMQC, and HMBC NMR, as well as low- and high-resolution ESI and EIMS experiments). The (S)-2-methylsuccinic acid moiety present in 1 was established by GC-MS analysis of a hydrolysis product.

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Mentioned in this Paper

Methylsuccinic acid
HMQC
Derivatives
Microsphaerone B
Pyrones
Protein NMR Spectroscopy
Filamentous fungus
Microsphaeropsis
Demospongiae
Aplysina aerophoba

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