Microspheres accurately predict regional bone blood flow

Clinical Orthopaedics and Related Research
H AnetzbergerK Messmer

Abstract

Even though the microsphere method frequently is used to determinate bone blood flow, validation of this technique for bone blood flow measurement is incomplete. The method is based on the principle that injected microspheres are distributed with the arterial blood and trapped in the capillaries because of their diameter (15 microm). The number of spheres lodged in an organ is proportional to its blood flow. The number of radioactive or fluorescent microspheres in a specific organ is determined indirectly by measuring radioactivity or fluorescence intensity in the organ. In this study the reliability and precision of the microsphere method for determining bone blood flow was established using radioactive and fluorescent microspheres. Six female, anesthetized New Zealand rabbits received left ventricular injections of pairs of fluorescent and/or radioactive microspheres. The humerus, femur, and tibia were dissected in a standardized manner and blood flow was determined in each sample. Comparison of relative blood flow values showed an excellent correlation between radioactive and fluorescent microspheres. The percentage difference and variation between two simultaneously injected sets of microspheres was minimal for radioactive ...Continue Reading

References

Oct 1, 1992·Acta Orthopaedica Scandinavica·O Grundnes, O Reikerås
Sep 1, 1991·The Journal of Bone and Joint Surgery. British Volume·A L WallaceS P Hughes
Jan 1, 1991·Research in Experimental Medicine. Zeitschrift Für Die Gesamte Experimentelle Medizin Einschliesslich Experimenteller Chirurgie·B ZwisslerK Messmer
Oct 1, 1990·Computer Methods and Programs in Biomedicine·W GrossK Messmer
Jul 1, 1990·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·T R DavisJ Pooley
Jan 1, 1989·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·H P NötzliR Wyatt
Jan 1, 1989·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·G LiP J Kelly
Jan 1, 1986·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·M F SwiontkowskiB A Rahn
Jul 1, 1985·Basic Research in Cardiology·Y NoseM Nakamura
Jul 1, 1973·Journal of Applied Physiology·J P ArchieE L Carlson
Jun 1, 1968·The Journal of Bone and Joint Surgery. American Volume·W J Kane
Aug 1, 1968·The American Journal of Physiology·J M NeutzeA M Rudolph
Nov 1, 1969·Investigative Radiology·H N WagnerJ P Ryan
Oct 1, 1971·Journal of Applied Physiology·G D BuckbergD E Fixler
Jul 1, 1971·Journal of Applied Physiology·P J KellyJ B Bassingthwaighte
Oct 1, 1984·Journal of Biomedical Engineering·P Tothill
Dec 1, 1984·Acta Orthopaedica Scandinavica·K Aalto, P Slätis
Oct 1, 1983·Pflügers Archiv : European journal of physiology·C BüngerS Harving
Dec 1, 1983·Southern Medical Journal·G J WangW G Stamp
Feb 1, 1983·Acta Orthopaedica Scandinavica·E Tøndevold, J Bülow
May 1, 1980·The Journal of Bone and Joint Surgery. British Volume·P J Gregg, D N Walder
Oct 1, 1994·Cardiovascular Research·F W Prinzen, R W Glenny
May 1, 1993·Journal of Applied Physiology·R W GlennyM Brinkley
Jan 14, 1999·Journal of Applied Physiology·T S GrossR F Zernicke
Jul 22, 1999·Mund-, Kiefer- und Gesichtschirurgie : MKG·D NolteK Messmer
Jan 25, 2000·American Journal of Physiology. Heart and Circulatory Physiology·N L PolissarR W Glenny
Feb 5, 2000·Computer Methods and Programs in Biomedicine·E TheinK Messmer
Apr 15, 2000·Computer Methods and Programs in Biomedicine·C SchimmelR W Glenny
Feb 22, 2001·Journal of Applied Physiology·R C ShymkiwR F Zernicke
May 18, 2001·American Journal of Physiology. Heart and Circulatory Physiology·C SchimmelR W Glenny
Feb 23, 2002·Clinical Orthopaedics and Related Research·Susan A BloomfieldMichael D Delp
Jun 22, 2002·European Surgical Research. Europäische Chirurgische Forschung. Recherches Chirurgicales Européennes·Eckart TheinK Messmer
Jun 13, 2003·European Surgical Research. Europäische Chirurgische Forschung. Recherches Chirurgicales Européennes·H AnetzbergerK Messmer

❮ Previous
Next ❯

Citations

Aug 29, 2006·Medical & Biological Engineering & Computing·Jan NäslundLars-Göran Lindberg
Dec 7, 2017·Frontiers in Endocrinology·Marie PereiraChantal Chenu
Jun 15, 2007·The American Journal of Sports Medicine·Jan NäslundLars-Göran Lindberg
Feb 17, 2017·Physiological Reviews·Ryan C Riddle, Thomas L Clemens
Jul 9, 2013·Archives of Orthopaedic and Trauma Surgery·Stephan VogtHermann Anetzberger
Jun 9, 2020·Molecular Nutrition & Food Research·Andrew G KunihiroJanet L Funk
Nov 7, 2009·Nature Protocols·Maria A Serrat
Dec 3, 2008·Proceedings of the National Academy of Sciences of the United States of America·Maria A SerratC Owen Lovejoy
Jul 28, 2021·The Journal of Experimental Biology·Qiaohui HuRoger S Seymour

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

European Surgical Research. Europäische Chirurgische Forschung. Recherches Chirurgicales Européennes
K SvanesT Svanes
European Journal of Cancer & Clinical Oncology
V M MeadeG W Self
© 2022 Meta ULC. All rights reserved