Microstimulation of V1 delays the execution of visually guided saccades

The European Journal of Neuroscience
Edward J TehovnikP H Schiller

Abstract

Electrical stimulation delivered to V1 concurrently with the presentation of a visual target interferes with both the selection and the detection of targets positioned in the receptive field of the stimulated neurons. In the present study, we examined the temporal course of this effect by delivering electrical stimulation to V1 of rhesus monkeys at various times before the appearance of a visual target. Each trial was initiated by the appearance of a fixation spot that, once acquired, was followed by the presentation of a visual target in the receptive field of the stimulated neurons. A monkey was reward after making a saccadic eye movement to the target. A delay in saccade generation was obtained when stimulation was delivered while an animal maintained fixation on the fixation spot. No delay occurred when the visual target was placed outside the receptive field of the stimulated neurons. The best parameters for inducing the saccadic delay were: (i). anode-first pulses (as opposed to cathode-first pulses) and (ii). train durations greater than 40 ms and frequencies greater than 100 Hz. The lowest current threshold for producing a saccadic delay occurred at 1.5 mm below the top of superficial V1. The chronaxies of the directly ...Continue Reading

Citations

Jun 9, 2005·Experimental Brain Research·Edward J Tehovnik, Warren M Slocum
Aug 10, 2006·Experimental Brain Research·Edward J Tehovnik, Warren M Slocum
Mar 21, 2007·Experimental Brain Research·Edward J Tehovnik, Warren M Slocum
May 5, 2010·Experimental Brain Research·Gene Y FridmanJack W Judy
Apr 25, 2007·Proceedings of the National Academy of Sciences of the United States of America·John S Pezaris, R Clay Reid
Mar 29, 2013·Neuroscience and Biobehavioral Reviews·Edward J Tehovnik, Warren M Slocum
Dec 19, 2006·Brain Research Reviews·Edward J Tehovnik, Warren M Slocum
Nov 26, 2005·The European Journal of Neuroscience·Edward J TehovnikPeter H Schiller
Jun 13, 2009·The European Journal of Neuroscience·Edward J Tehovnik, Warren M Slocum
Feb 7, 2012·Progress in Neurobiology·Mark H HistedJohn H R Maunsell
Dec 22, 2017·Journal of Neural Engineering·Daniel J O'Shea, Krishna V Shenoy
Sep 17, 2004·Journal of Neurophysiology·E J TehovnikP H Schiller
Jul 13, 2006·Journal of Neurophysiology·E J TehovnikN K Logothetis
Jun 15, 2007·Journal of Neurophysiology·Edward J Tehovnik, Warren M Slocum
Aug 30, 2013·Journal of Neural Engineering·Boubker ZaaimiLee E Miller
Sep 13, 2013·Journal of Neurophysiology·Andrea A BrockAnna W Roe
Jul 29, 2017·Annual Review of Vision Science·William H BoskingDaniel Yoshor
Jun 3, 2020·Cerebral Cortex·Jia Ming HuAnna Wang Roe
Oct 30, 2009·Journal of Neurophysiology·Nicolas Y Masse, Erik P Cook
Apr 13, 2021·Journal of Medical Engineering & Technology·Léo Pio-LopezDamien Depannemaecker
May 25, 2021·Advanced Healthcare Materials·Xin Sally ZhengXinyan Tracy Cui

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