Microstructural abnormalities in children with post-traumatic stress disorder: a diffusion tensor imaging study at 3.0T

Scientific Reports
Du LeiQiyong Gong

Abstract

Posttraumatic stress disorder (PTSD) is a severe anxiety disorder characterized by re-experiencing, avoidance and hyperarousal. Brain microstructure abnormalities in PTSD, especially in children, are not yet well characterized. The aim of this study was to use MR diffusion tensor imaging (DTI) to identify brain microstructure alterations in children with PTSD compared to non-PTSD controls who experienced the same time-limited trauma. We studied 27 children with PTSD and 24 age- and gender-matched traumatized controls without PTSD, who all experienced the 2008 Sichuan major earthquake. DTI data were acquired and analyzed in terms of fractional anisotropy (FA), mean diffusivity (MD), radial diffusivity (RD) and axial diffusivity (AD). Children with PTSD showed an abnormal pattern, not only of FA, but also of the diffusivity measures MD, AD and RD. Most of the abnormal brain regions belonged to two important networks: the default-mode network, including precuneus and angular gyrus, and the salience network, including insula, putamen and thalamus. This DTI study identifies microstructural abnormalities of children with PTSD after a major earthquake, our results are consistent with the suggestion that pediatric PTSD is accompanied b...Continue Reading

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Citations

Oct 19, 2016·Radiology·Su LuiQiyong Gong
Oct 26, 2018·Journal of Child Psychology and Psychiatry, and Allied Disciplines·Carl F WeemsBethany H McCurdy
Jun 5, 2019·Acta Paediatrica·G AlfvenE Andersson
Jul 1, 2020·International Journal of Molecular Sciences·Sabah NisarMohammad Haris
Feb 13, 2021·International Journal of Molecular Sciences·Takanobu Yoshii

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Software Mentioned

SPM
BET Brain Extraction Tool
Marsbar
MATLAB

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