Microstructural changes across different clinical milestones of disease in amyotrophic lateral sclerosis

PloS One
Francesca TrojsiGioacchino Tedeschi

Abstract

Neurodegenerative process in amyotrophic lateral sclerosis (ALS) has been proven to involve several cortical and subcortical brain regions within and beyond motor areas. However, how ALS pathology spreads progressively during disease evolution is still unknown. In this cross-sectional study we investigated 54 ALS patients, divided into 3 subsets according to the clinical stage, and 18 age and sex-matched healthy controls, by using tract-based spatial statistics (TBSS) diffusion tensor imaging (DTI) and voxel-based morphometry (VBM) analyses. We aimed to identify white (WM) and gray matter (GM) patterns of disease distinctive of each clinical stage, corresponding to specific clinical milestones. ALS cases in stage 2A (i.e., at diagnosis) were characterized by GM and WM impairment of left motor and premotor cortices and brainstem at ponto-mesenchephalic junction. ALS patients in clinical stage 2B (with impairment of two functional regions) exhibited decreased fractional anisotropy (FA) (p<0.001, uncorrected) and increased mean (MD) and radial diffusivity (RD) (p<0.001, uncorrected) in the left cerebellar hemisphere and brainstem precerebellar nuclei, as well as in motor areas, while GM atrophy (p<0.001, uncorrected) was detected ...Continue Reading

References

Apr 1, 1991·Brain : a Journal of Neurology·J A Kiernan, A J Hudson
Jun 1, 1970·Journal of Neurology, Neurosurgery, and Psychiatry·B BrownellJ T Hughes
Jun 22, 2000·NeuroImage·J Ashburner, K J Friston
Sep 14, 2000·Proceedings of the National Academy of Sciences of the United States of America·B Fischl, A M Dale
Mar 27, 2001·Muscle & Nerve·A Eisen, M Weber
Jul 24, 2001·Amyotrophic Lateral Sclerosis and Other Motor Neuron Disorders : Official Publication of the World Federation of Neurology, Research Group on Motor Neuron Diseases·B R BrooksUNKNOWN World Federation of Neurology Research Group on Motor Neuron Diseases
Aug 28, 2001·Journal of the American Medical Informatics Association : JAMIA·J MazziottaB Mazoyer
Sep 8, 2001·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·J MazziottaB Mazoyer
Apr 13, 2005·Neurology·S AbrahamsL H Goldstein
Aug 24, 2005·Neurology·G M RingholzP E Schulz
Apr 21, 2006·NeuroImage·Stephen M SmithTimothy E J Behrens
May 2, 2006·Brain Research Bulletin·A TessitoreG Tedeschi
Sep 16, 2006·International Journal of Geriatric Psychiatry·Eneida MioshiJohn R Hodges
Oct 20, 2007·Lancet Neurology·Julie PhukanOrla Hardiman
Sep 12, 2008·Neurology·M GrossmanL McCluskey
Feb 11, 2009·Archives of Neurology·Felix GeserJohn Q Trojanowski
Jun 9, 2009·Nature Cell Biology·Florence ClavagueraMarkus Tolnay
Oct 20, 2009·Journal of the Neurological Sciences·Isabella Laura SimoneMarina de Tommaso
Apr 2, 2010·Journal of Cell Science·Mimi CushmanJames Shorter
Jun 10, 2010·Journal of Neurology·Paul H GordonVincent Meininger
Nov 26, 2010·Journal of Neurology, Neurosurgery, and Psychiatry·Colette DonaghyR John Leigh
Jan 29, 2011·Amyotrophic Lateral Sclerosis : Official Publication of the World Federation of Neurology Research Group on Motor Neuron Diseases·Joe SendaGen Sobue
Feb 8, 2011·Lancet·Matthew C KiernanMargaret C Zoing
Mar 15, 2011·Cortex; a Journal Devoted to the Study of the Nervous System and Behavior·Stella TsermentseliLaura H Goldstein
Mar 16, 2011·Journal of Neurology, Neurosurgery, and Psychiatry·Adriano ChiòUNKNOWN PARALS study group
Jun 7, 2011·Journal of the Neurological Sciences·Masashi TsujimotoGen Sobue
Jul 13, 2011·Archives of Neurology·Rakesh SharmaMartin R Turner
Oct 4, 2011·Journal of Neurology, Neurosurgery, and Psychiatry·Esther VerstraeteLeonard H van den Berg
Oct 7, 2011·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·A ChiòA Calvo
Nov 18, 2011·European Journal of Nuclear Medicine and Molecular Imaging·Angelina CistaroMarco Pagani
Nov 26, 2011·Amyotrophic Lateral Sclerosis : Official Publication of the World Federation of Neurology Research Group on Motor Neuron Diseases·Emilie BeaufilsJulien Praline
Jan 25, 2012·Brain : a Journal of Neurology·Jose C RocheAmmar Al-Chalabi

❮ Previous
Next ❯

Citations

Jan 26, 2016·Expert Review of Neurotherapeutics·Jan Kassubek, Hans-Peter Müller
Nov 18, 2015·Muscle & Nerve·Michael BenatarLucie Bruijn
Jun 8, 2017·Journal of Magnetic Resonance Imaging : JMRI·Yuanyuan QinWenzhen Zhu
Sep 5, 2020·Amyotrophic Lateral Sclerosis & Frontotemporal Degeneration·Francesca TrojsiGioacchino Tedeschi
Aug 20, 2020·Cortex; a Journal Devoted to the Study of the Nervous System and Behavior·Monica ConsonniGiuseppe Lauria
Dec 18, 2020·Frontiers in Neurology·Rachel F Smallwood ShoukryMary Kay Floeter
Jun 4, 2021·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·Xenia KobelevaMircea Ariel Schoenfeld
Sep 3, 2021·Journal of Neural Transmission·Francesca TrojsiGioacchino Tedeschi

❮ Previous
Next ❯

Software Mentioned

VBM8
SPM8
Functional MRI of the Brain ( FMRIB ) Software Library ( FSL )
TBSS
DARTEL
FSL

Related Concepts

Related Feeds

Ataxias (MDS)

Ataxia is a neurological condition characterized by lack of voluntary coordination of muscle movements including loss of coordination, balance, and speech. Discover the latest research on ataxia here.

ALS: Genetics

Amyotrophic Lateral Sclerosis (ALS) is a progressive neurodegenerative disorder characterized by muscle weakness. ALS is a genetically heterogeneous disorder with several causative genes. Here are the latest discoveries pertaining to the genetics of this disease.

Axon Guidance

Axon guidance is a complex neural developmental field that investigates mechanisms through which neurons send out axons to reach its target. Here is the latest research in this domain.

Ataxia

Ataxia is a neurological condition characterized by lack of voluntary coordination of muscle movements including loss of coordination, balance, and speech. Discover the latest research on ataxia here.

Ataxias

Ataxia is a neurological condition characterized by lack of voluntary coordination of muscle movements including loss of coordination, balance, and speech. Discover the latest research on different types of ataxias here.

Auditory Perception

Auditory perception is the ability to receive and interpret information attained by the ears. Here is the latest research on factors and underlying mechanisms that influence auditory perception.

Birth Defects

Birth defects encompass structural and functional alterations that occur during embryonic or fetal development and are present since birth. The cause may be genetic, environmental or unknown and can result in physical and/or mental impairment. Here is the latest research on birth defects.

Amyloid Lateral Sclerosis

Amyotrophic Lateral Sclerosis (ALS) is a progressive nervous system disease associated with the death of neurons that control voluntary muscles. Discover the latest research on ALS here.

ALS & FTD: TDP-43

TAR DNA-binding protein 43 (TDP-43) is a pathological protein identified in sporadic Amyotrophic Lateral Sclerosis (ALS) and Frontotemporal Dementia (FTD). Here are the latest discoveries pertaining to TDP-43 and these diseases.

ALS: Genetics

Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disorder characterized by muscle weakness. Here is the latest research investigating genetic alterations in this genetically heterogeneous disorder.

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.

Related Papers

Amyotrophic Lateral Sclerosis : Official Publication of the World Federation of Neurology Research Group on Motor Neuron Diseases
Dafna Ben BashatOrna Aizenstein
Amyotrophic Lateral Sclerosis : Official Publication of the World Federation of Neurology Research Group on Motor Neuron Diseases
Joe SendaGen Sobue
© 2021 Meta ULC. All rights reserved