Microstructural changes in the substantia nigra of asymptomatic agricultural workers

Neurotoxicology and Teratology
Guangwei DuXuemei Huang

Abstract

Parkinson's disease (PD) is marked by the loss of dopamine neurons in the substantia nigra (SN). Although the exact etiology is unknown, sporadic PD is hypothesized to be a result of genetic susceptibility interacting with environmental insult. Epidemiological studies suggest that pesticide exposure is linked to higher PD risk, but there are no studies demonstrating SN changes with chronic pesticide exposure in human subjects. Thus, high resolution T2-weighted magnetic resonance imaging (MRI) and diffusion tensor (DTI) images were obtained from 12 agricultural workers with chronic pesticide exposure, 12 controls, and 12 PD subjects. Neither controls nor pesticide-exposed subjects, had any parkinsonian symptoms. Exposure history to pesticides was assessed by a structured questionnaire. DTI measures in the SN, including fractional anisotropy (FA), mean diffusivity (MD), axial diffusivity (AD), and radial diffusivity (RD), were obtained for all subjects and compared among groups. Compared to controls, PD patients showed the expected significant changes in all DTI measurements in the SN. The pesticide-exposed subjects, compared to controls, had significantly lower FA values (p=0.022, after multiple comparisons correction), but no s...Continue Reading

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Citations

Jun 1, 2016·Environmental Science and Pollution Research International·Asma LahouelRachid Soulimani
Jul 8, 2016·Journal of Magnetic Resonance Imaging : JMRI·Serguei Liachenko, Jaivijay Ramu
Jun 22, 2017·Toxicological Sciences : an Official Journal of the Society of Toxicology·Mechelle M LewisXuemei Huang
Mar 7, 2014·Journal of Biochemical and Molecular Toxicology·Byron C JonesRobert W Williams
Apr 19, 2017·Journal of Agromedicine·Susan Searles NielsenChristopher D Simpson
Jun 20, 2019·Frontiers in Aging Neuroscience·Laura PelizzariFrancesca Baglio
Mar 20, 2021·Toxicological Sciences : an Official Journal of the Society of Toxicology·Ernest W WangXuemei Huang

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