Microstructural Distinction of Electrospun Nanofibrous Drug Delivery Systems Formulated with Different Excipients

Molecular Pharmaceutics
Adrienn KazsokiRomána Zelkó

Abstract

The electrospun nanofiber-based orally dissolving webs are promising candidates for rapid drug release, which is due to the high surface area to volume ratio of the fibers and the high amorphization efficacy of the fiber formation process. Although the latter is responsible for the physical and/or chemical instability of these systems. The primary aim of the present study was to elucidate how the addition of polysorbate 80 (PS80) and hydroxypropyl-β-cyclodextrin (HP-β-CD) influenced the electrospinning process, the properties, and the behavior of the obtained nanofibers. In order to reveal any subtle changes attributable to the applied excipients, the prepared samples were subjected to several state of the art imaging and solid state characterization techniques at both macroscopic and microscopic levels. Atomic force microscopy (AFM) revealed the viscoelastic nature of the fibrous samples. At relatively low forces mostly elastic deformation was observed, while at higher loads plasticity predominated. The use of polysorbate led to about two times stiffer, less plastic fibers than the addition of cyclodextrin. The 1H-13C nuclear magnetic resonance (NMR) cross-polarization build-up curves pointed out that cyclodextrin acts as an i...Continue Reading

References

Sep 1, 1971·Journal of Pharmaceutical Sciences·W L Chiou, S Riegelman
Aug 16, 2005·International Journal of Pharmaceutics·Thorsteinn LoftssonMár Másson
Jan 24, 2009·Journal of Pharmaceutical and Biomedical Analysis·János BajdikKlára Pintye-Hódi
Jan 4, 2012·Journal of Pharmaceutical Sciences·Blair BrettmannBernhardt Trout
Mar 14, 2012·Journal of Pharmaceutical Sciences·Blair Kathryn BrettmannBernhardt L Trout
Jun 6, 2013·TheScientificWorldJournal·Jae-Hoon LeeSeonghun Park
Feb 24, 2015·International Journal of Pharmaceutics·J PelipenkoJ Kristl
Jun 29, 2015·International Journal of Pharmaceutics·Enikő BorbásZsombor K Nagy
Jul 16, 2015·Journal of Pharmaceutical Sciences·Yan He, Chris Ho
Feb 1, 2014·Acta Pharmaceutica Sinica. B·Yanbin Huang, Wei-Guo Dai
Mar 10, 2016·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Pei T MahTimo Laaksonen
Sep 7, 2016·Journal of Pharmaceutical and Biomedical Analysis·Péter SzabóRomána Zelkó
Aug 23, 2017·Chemical Society Reviews·Matthew J Webber, Robert Langer

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Citations

Jan 9, 2020·Pharmaceutical Research·Xin-Yi TeohSiok-Yee Chan
Apr 14, 2020·Materials Science & Engineering. C, Materials for Biological Applications·Hasham S SofiFaheem A Sheikh
Jun 16, 2021·Biomaterials Science·Emily Diep, Jessica D Schiffman

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