Microstructural parameter-based modeling for transport properties of collagen matrices

Journal of Biomechanical Engineering
Seungman ParkBumsoo Han

Abstract

Recent advances in modulating collagen building blocks enable the design and control of the microstructure and functional properties of collagen matrices for tissue engineering and regenerative medicine. However, this is typically achieved by iterative experimentations and that process can be substantially shortened by computational predictions. Computational efforts to correlate the microstructure of fibrous and/or nonfibrous scaffolds to their functionality such as mechanical or transport properties have been reported, but the predictability is still significantly limited due to the intrinsic complexity of fibrous/nonfibrous networks. In this study, a new computational method is developed to predict two transport properties, permeability and diffusivity, based on a microstructural parameter, the specific number of interfibril branching points (or branching points). This method consists of the reconstruction of a three-dimensional (3D) fibrous matrix structure based on branching points and the computation of fluid velocity and solute displacement to predict permeability and diffusivity. The computational results are compared with experimental measurements of collagen gels. The computed permeability was slightly lower than the ...Continue Reading

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Citations

Sep 19, 2019·Scientific Reports·Seungman ParkYun Chen
Nov 13, 2020·Frontiers in Bioengineering and Biotechnology·Yongbo Yang, Soliman Abdalla

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