Microstructural quantification of collagen fiber orientations and its integration in constitutive modeling of the porcine carotid artery

Acta Biomaterialia
P SáezM A Martínez

Abstract

Mechanical characteristics of vascular tissue may play a role in different arterial pathologies, which, amongst others, requires robust constitutive descriptions to capture the vessel wall's anisotropic and non-linear properties.Specifically, the complex 3D network of collagen and its interaction with other structural elements has a dominating effect of arterial properties at higher stress levels.The aim of this study is to collect quantitative collagen organization as well as mechanical properties to facilitate structural constitutive models for the porcine carotid artery.This helps the understanding of the mechanics of swine carotid arteries, being a standard in clinical hypothesis testing, in endovascular preclinical trials for example. Porcine common carotid arteries (n=10) were harvested and used to (i) characterize the collagen fiber organization with polarized light microscopy, and (ii) the biaxial mechanical properties by inflation testing.The collagen organization was quantified by the Bingham orientation density function (ODF), which in turn was integrated in a structural constitutive model of the vessel wall.A one-layered and thick-walled model was used to estimate mechanical constitutive parameters by least-square f...Continue Reading

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Citations

Feb 2, 2018·Journal of the Royal Society, Interface·Kewei LiGerhard A Holzapfel
Dec 14, 2017·Biomechanics and Modeling in Mechanobiology·Akinjide R Akintunde, Kristin S Miller
Feb 25, 2020·Journal of the Mechanical Behavior of Biomedical Materials·Olfa TrabelsiStephane Avril
Jun 3, 2021·Journal of Biomechanical Engineering·Eun-Ho Lee, Seungik Baek
Jul 26, 2021·Acta Biomaterialia·Marco AmabiliGerhard A Holzapfel

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