Microstructure and Mechanical Properties of PU/PLDL Sponges Intended for Grafting Injured Spinal Cord

Polymers
Anna Lis-BartosJadwiga Laska

Abstract

Highly porous, elastic, and degradable polyurethane and polyurethane/polylactide (PU/PLDL) sponges, in various shapes and sizes, with open interconnected pores, and porosity up to 90% have been manufactured. They have been intended for gap filling in the injured spinal cord. The porosity of the sponges depended on the content of polylactide, i.e., it decreased with the increase of polylactide content. The rise of polylactide content caused an increase of Young modulus and rigidity as well as a more complex morphology of the polyurethane/polylactide blends. The mechanical properties, in vitro toxicity, and degradation in artificial cerebrospinal fluid were tested. Sponges underwent continuous degradation with varying degradation rates depending on the polymer composition. In vitro cell studies with fibroblast cultures proved the biocompatibility of the polymers. Based on the obtained results, the designed PU/PLDL sponges appeared to be promising candidates for bridging gaps within injured spinal cord in further in vitro and in vivo studies.

References

Oct 1, 1972·The Surgical Clinics of North America·J H Hubbard
Mar 1, 1969·Journal of Neurosurgery·T B DuckerG J Hayes
Feb 23, 1999·Clinical and Experimental Pharmacology & Physiology·N R SaundersK M Dziegielewska
Apr 29, 1999·Brain Pathology·G Stoll, H W Müller
Jan 5, 2002·Journal of Physiology, Paris·J V PriestleyR A Brown
Jul 22, 2006·Nature Reviews. Neuroscience·Glenn Yiu, Zhigang He
Nov 22, 2007·Advanced Drug Delivery Reviews·Stephanie M Willerth, Shelly E Sakiyama-Elbert
May 16, 2008·Cerebrospinal Fluid Research·Conrad E JohansonGerald D Silverberg
Aug 25, 2009·Journal of Neurotrauma·Karin S StraleySarah C Heilshorn
Nov 4, 2009·Annals of Physical and Rehabilitation Medicine·L BauchetC Fattal
Jun 23, 2010·Cerebrospinal Fluid Research·Michael Pollay
Jun 7, 2011·Acta Biomaterialia·Ari KarchinJoan E Sanders
Aug 30, 2011·Journal of Neuroscience Methods·T KoechlingF Lim
Nov 22, 2011·European Annals of Otorhinolaryngology, Head and Neck Diseases·L SakkaJ Chazal
Aug 6, 2013·Biotechnology and Applied Biochemistry·Dariusz SzarekJadwiga Laska
Sep 5, 2013·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Roger Y TamMolly S Shoichet
Sep 7, 2013·Cell Transplantation·Pawel TabakowGeoffrey Raisman
May 13, 2014·Fluids and Barriers of the CNS·Thomas BrinkerPetra Klinge
Jul 1, 2015·Stem Cells International·Rita C Assunção-SilvaAntónio J Salgado
Dec 17, 2015·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Dariusz SzarekWłodzimierz Jarmundowicz
Jan 28, 2016·Regenerative Biomaterials·Lingling TianSeeram Ramakrishna
Dec 24, 2018·Journal of Biomedical Science·Rossana BoniAndrew N Clarkson
Aug 23, 2019·Artificial Cells, Nanomedicine, and Biotechnology·Hamed AmaniHamidreza Pazoki-Toroudi

❮ Previous
Next ❯

Methods Mentioned

BETA
scanning electron microscopy
fluorescence microscopy
protein assay

Related Concepts

Related Feeds

CSF & Lymphatic System

This feed focuses on Cerebral Spinal Fluid (CSF) and the lymphatic system. Discover the latest papers using imaging techniques to track CSF outflow into the lymphatic system in animal models.

Related Papers

Current Biology : CB
Sally P LeysBernard M Degnan
The Medical Journal of Australia
A M Macintosh
© 2021 Meta ULC. All rights reserved