Microstructure-dependent mechanical properties of electrospun core-shell scaffolds at multi-scale levels

Journal of the Mechanical Behavior of Biomedical Materials
Christopher B HornerJin Nam

Abstract

Mechanical factors among many physiochemical properties of scaffolds for stem cell-based tissue engineering significantly affect tissue morphogenesis by controlling stem cell behaviors including proliferation and phenotype-specific differentiation. Core-shell electrospinning provides a unique opportunity to control mechanical properties of scaffolds independent of surface chemistry, rendering a greater freedom to tailor design for specific applications. In this study, we synthesized electrospun core-shell scaffolds having different core composition and/or core-to-shell dimensional ratios. Two independent biocompatible polymer systems, polyetherketoneketone (PEKK) and gelatin as the core materials while maintaining the shell polymer with polycaprolactone (PCL), were utilized. The mechanics of such scaffolds was analyzed at the microscale and macroscales to determine the potential implications it may hold for cell-material and tissue-material interactions. The mechanical properties of individual core-shell fibers were controlled by core-shell composition and structure. The individual fiber modulus correlated with the increase in percent core size ranging from 0.55±0.10GPa to 1.74±0.22GPa and 0.48±0.12GPa to 1.53±0.12GPa for the P...Continue Reading

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Citations

Aug 25, 2017·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·A A Valencia-LazcanoA Rodríguez-Ortega
Jan 5, 2019·Biomedical Materials·Muna M KareemK Elizabeth Tanner
Nov 11, 2019·ACS Biomaterials Science & Engineering·Ksenia S StankevichMark T Quinn
Nov 13, 2019·ACS Applied Materials & Interfaces·Christopher B HornerJin Nam

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