Microstructure, rheological and wound healing properties of collagen-based gel from cuttlefish skin

International Journal of Biological Macromolecules
Mourad JridiMoncef Nasri

Abstract

Collagen-based biomaterials are of the utmost importance for tissue engineering and regenerative medicine. The aims of the present investigation were to evaluate structural and rheological properties of collagen-based gel obtained from cuttlefish skin, and to investigate its ability to enhance wound healing. Scanning electron microscopy of resulted gel showed a dense fibrillar microstructure with high interconnection network with a smaller pore size. In addition, the rheological characterization of collagen gel showed an excellent reversibility, when subjected to a temperature variation. Moreover, in the wound-healing study, topical application of collagen based gel increased significantly the percentage of wound closure over a period of 12 days, when compared to the untreated and CICAFLORA(®)-treated groups. Wound-healing activity of collagen gel was confirmed by histopathology study. Thus, cuttlefish collagen based gel might be useful as a wound healing agent.

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Citations

Oct 25, 2016·Materials Science & Engineering. C, Materials for Biological Applications·Nurettin SahinerCoskun Silan
Oct 18, 2016·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Raida ZouariDhouha Ghribi-Aydi
Feb 7, 2018·Burns and Trauma·Peng HeXiaolu Li
Sep 22, 2017·Current Medicinal Chemistry·Antonio FranceskoTzanko Tzanov
Sep 24, 2020·Marine Drugs·Tharindu R L SenadheeraFereidoon Shahidi
Sep 27, 2020·Materials·Alina SionkowskaMagdalena Gadomska
Jun 4, 2020·Materials Science & Engineering. C, Materials for Biological Applications·Luca SalvatoreAlessandro Sannino
Apr 4, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Haisheng LinXiaoming Qin
Mar 30, 2021·Journal of Tissue Engineering and Regenerative Medicine·Leila RoshangarAhad Ferdowsi Khosroshahi
Sep 13, 2017·International Journal of Biological Macromolecules·Nabil SouissiMoncef Nasri

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