Microsurgery for the treatment of primary malignant intracranial melanoma: a surgical series and literature review

European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology
J WangD-G Xing

Abstract

Primary malignant intracranial melanomas are rare tumors of the central nervous system. These tumors are highly malignant and are associated with poor prognosis. The field of neurosurgery has struggled with the diagnosis and treatment of these tumors. In this study, we present a surgical series of eight patients with primary malignant intracranial melanomas and retrospectively analyze the clinical features, imaging findings, pathological features and prognoses of these patients. All patients underwent microsurgery. Total and subtotal resection of the tumor was achieved in six and two patients, respectively. Of the eight patients, seven showed improvement while one remained the same at time of discharge. There was no neurosurgical deterioration. Radiotherapy was conducted in six patients after operation. The average follow-up duration was 13.8 months (range = 9-26 months). During the follow-up period, three patients died from this disease. One patient suffered from recurrence at the 16th month and underwent second surgery. The other patients were still alive with no evidence of tumor recurrence. Microsurgery and radiotherapy should be the first line managements for patients with primary malignant intracranial melanomas. Improvem...Continue Reading

References

Dec 1, 1995·AJR. American Journal of Roentgenology·I IsiklarA J Kumar
Jan 4, 1995·Journal of the National Cancer Institute·E AlexanderJ S Loeffler
Mar 1, 1994·International Journal of Radiation Oncology, Biology, Physics·J C FlickingerP K Sneed
Apr 2, 2002·Journal of Immunotherapy·Lisa M GuirguisDouglas J Schwartzentruber
Mar 31, 2004·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·K M FifeJ F Thompson
Jun 1, 2004·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Sanjiv S AgarwalaElaine M Rankin
Jul 16, 2004·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Jill S Barnholtz-SloanRaymond E Sawaya
Aug 13, 2004·Zentralblatt für Neurochirurgie·D FreudensteinF Duffner
Aug 25, 2004·Cancer Treatment Reviews·D Bafaloukos, H Gogas
Jan 4, 2007·Cancer·Helen J GogasVernon K Sondak
Jun 8, 2010·The New England Journal of Medicine·F Stephen HodiWalter J Urba
Jun 19, 2010·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Simon V LiubinasKatharine J Drummond
Aug 20, 2010·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Jenny J HongRichard M Sherry
Nov 3, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Martin KocherRolf-Peter Mueller
Jun 7, 2011·The New England Journal of Medicine·Paul B ChapmanUNKNOWN BRIM-3 Study Group
Jun 7, 2011·The New England Journal of Medicine·Caroline RobertJedd D Wolchok
Nov 4, 2011·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·John M KirkwoodReinhard Dummer
Jan 6, 2012·Journal of Skin Cancer·Daniela Gonsalves Shapiro, Wolfram E Samlowski
Jan 13, 2012·Progress in Neurological Surgery·Edward M Marchan, Jason Sheehan
Apr 13, 2012·Melanoma Research·Geoffrey Thomas GibneyVernon K Sondak
Oct 6, 2012·Mayo Clinic Proceedings·Nicole M RochetSvetomir N Markovic
May 30, 2013·American Society of Clinical Oncology Educational Book·Naren Ramakrishna, Kim A Margolin

❮ Previous
Next ❯

Citations

Oct 5, 2015·The Lancet Oncology·Thankamma AjithkumarSarah Jefferies
May 20, 2015·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Na-Kyoung LeeSeung-Ki Kim
Jan 30, 2015·Journal of Korean Neurosurgical Society·Jae-Hyun Park, Yong-Kil Hong
Jan 7, 2017·Journal of Korean Neurosurgical Society·Kengo HirotaHidetoshi Kasuya

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Healthcare Informatics : the Business Magazine for Information and Communication Systems
D Reschneck-Sannes
International Journal of Emergency Medicine
Imron Subhan, Anunaya Jain
© 2021 Meta ULC. All rights reserved