Microsurgical reconstruction of the lymphatic and nerve system in small bowel transplantation: the rat model, first results

Transplant International : Official Journal of the European Society for Organ Transplantation
T P Szymula von RichterC Hammer

Abstract

The goal in tissue transplantation is the restoration of all natural (physiological) communication pathways between the host and the graft. To this end, the effects of microsurgical reconstruction of artery, vein, lymphatic vessel, and nerve during grafting were investigated. Allogenic (MHC class II incompatible) and isogenic orthotopic (graft in functional continuity) small bowel recipients with immediate microsurgical lymphatic and nerve anastomosis were observed clinically as well as by immunological and histological examination. To explain the influence of the lymphatic system in allograft survival, short-term therapy was applied with the immunosuppressant cyclosporin A (10 mg/kg i.m.) for only 5 postoperative days. Average allograft survival ended in the control group after 10 days without any therapy, increased up to 20 days after immunosuppressive therapy (in both groups acute rejection and graft-versus-host disease were seen) and increased further to more than 200 days following lymphatic connection of the host and the graft during allografting. In this group no lymphatic edema of the graft was seen. To determine the optimal location of nerve anastomoses between the host and the graft without irritating the host nerve s...Continue Reading

References

Jan 1, 1990·Plastic and Reconstructive Surgery·R G Baumeister, S Siuda
Jan 1, 1990·Journal of Psychopharmacology·B E Leonard

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