Microthromboemboli in acute infarcts: analysis of 40 autopsy cases

Stroke; a Journal of Cerebral Circulation
N Heye, J Cervós-Navarro

Abstract

We investigated the distribution and frequency of microthromboemboli (MTE) in acute infarcts in humans and determined whether MTE in the contralateral circulation resulted in histological changes. Forty patients dying within the first month after unilateral infarct were investigated. Infarct etiology was determined mainly on the pathological findings. Whole brain sections from the region of maximal necrosis were stained for fibrin. Fibrin-containing MTE were transferred to a schematic drawing and counted. Sections from 20 patients without infarcts served as controls. Infarct sections had significantly more MTE than controls. Infarcts of thrombotic (n=6) and thromboembolic (n=21) origin had more MTE than infarcts of embolic origin (n=13). Thromboembolic infarcts had the highest number of MTE within the region assumed to be the ischemic penumbra, other arterial territories, and the contralateral hemisphere. Patients with large infarcts and those with short clinical courses had a higher number of MTE. Sixteen patients had recent micronecroses in the contralateral hemisphere. There seems to be a pattern of MTE in acute infarcts that is dependent on cause, size, and clinical duration. Our findings of contralateral micronecroses emph...Continue Reading

References

Nov 1, 1992·Acta Neurologica Scandinavica·N HeyeJ Cervos-Navarro
Oct 1, 1990·Archives of Neurology·M Fisher, R Francis
Mar 1, 1983·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·A J StrongJ A Hardy
Jan 1, 1983·Journal of Neuropathology and Experimental Neurology·J H GarciaK A Conger
Aug 20, 1994·Lancet·M SieblerH Steinmetz
Oct 1, 1994·Annals of Neurology·M D Ginsberg, W A Pulsinelli
Nov 12, 1994·Lancet·D GeorgiadisE B Ringelstein
May 1, 1994·European Journal of Vascular Surgery·D GeorgiadisK R Lees
Jul 1, 1964·Archives of Neurology·F C ROMANUL, A ABRAMOWICZ

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Citations

Jun 16, 1999·Journal of Neurotrauma·J V Lafuente, J Cervós-Navarro
Apr 27, 2011·Clinical and Experimental Pharmacology & Physiology·Wen-Quan LuWan-Sheng Chen
Jan 1, 1999·Neuropathology : Official Journal of the Japanese Society of Neuropathology·J LafuenteJ Cervós-Navarro
Jan 29, 2005·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Akira MoriguchiSeitaro Mutoh
Oct 11, 2012·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Turgay Dalkara, Ethem Murat Arsava
Apr 20, 2007·Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging·Pablo IrimiaJavier Zulueta
Jul 23, 2011·Developmental Neurobiology·Kim M Baeten, Katerina Akassoglou
Feb 9, 2006·Neurological Research·Yuchuan Ding, Justin C Clark
Jan 29, 2011·Journal of Biomedicine & Biotechnology·Sang In ParkKyung-Sool Jang
Dec 14, 2017·International Journal of Molecular Sciences·Mohamad El Amki, Susanne Wegener
Jun 12, 2018·Journal of Stroke·Ángel Chamorro

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