Microtopography of titanium suppresses osteoblastic differentiation but enhances chondroblastic differentiation of rat femoral periosteum-derived cells

Journal of Biomedical Materials Research. Part a
Katsutoshi KuboTakahiro Ogawa

Abstract

Despite the clinical fact that endosseous titanium implants directly contacts periosteum, the behavior and response of the periosteum-derived cells to surface topography of titanium have rarely been studied. This study examines the effect of titanium surface microtopography on osteoblastic and possibly-modulated chondroblastic phenotypes of femoral periosteum-derived cells. Rat femoral periosteum-derived cells were cultured on either relatively smooth, machined titanium surface or acid-etched, micro-roughened titanium surface. The osteoblastic gene expressions, including collagen I, osteopontin and osteocalcin, were downregulated on the acid-etched surface, compared with the machined surface. Alkaline phosphatase and mineralization activities on the acid-etched surface were approximately 20% of those on the machined surface. Instead, chondroblastic specific genes, including collagen II and IX, and sox 9, were exclusively expressed or highly upregulated on the acid-etched surface. Alcian blue stain revealed an extensive deposition of glycosaminoglycan on the acid-etched surface. The cultured matrix on the acid-etched surface lacked the submicron globular structures that were extensively seen on the machined surface, and containe...Continue Reading

References

Jan 1, 1989·Journal of Biomedical Engineering·C JohanssonT Albrektsson
May 1, 1987·The Journal of Prosthetic Dentistry·T Albrektsson, M Jacobsson
Jan 1, 1984·Hormone Research·L G Raisz
Sep 1, 1996·Journal of Biomedical Materials Research·K KieswetterB D Boyan
Feb 11, 1998·Experimental Cell Research·B JohnstoneJ U Yoo
Nov 24, 1998·Critical Reviews in Oral Biology and Medicine : an Official Publication of the American Association of Oral Biologists·M M KlingerJ E Lemons
Jan 23, 1999·Tissue Engineering·A M MackayM F Pittenger
Jan 26, 1999·Clinical Orthopaedics and Related Research·T A Einhorn
May 13, 1999·Nature Genetics·W BiB de Crombrugghe
Dec 30, 1999·Biomaterials·D A Puleo, A Nanci
Oct 20, 2000·Clinical Orthopaedics and Related Research·J U YooB Johnstone
Mar 10, 2001·Journal of Cellular Biochemistry·K HanadaB Johnstone
Jun 5, 2002·The Journal of Bone and Joint Surgery. British Volume·M OchiJ Iwasa
Sep 27, 2003·Tissue Engineering·Dietmar W Hutmacher, Michael Sittinger
Mar 30, 2004·Biomaterials·Xiaolong ZhuJuergen Geis-Gerstorfer
Sep 7, 2004·Journal of Materials Science. Materials in Medicine·A RedlichM Sittinger
Jan 18, 2005·Journal of Biomedical Materials Research. Part a·Kazuo TakeuchiTakahiro Ogawa
Oct 20, 2005·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Lei SaruwatariTakahiro Ogawa
Nov 23, 2006·Biotechnology Letters·Yong-Soo ChoiDong-Il Kim

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Citations

Dec 1, 2012·Stem Cells Translational Medicine·Hana Chang, Melissa L Knothe Tate
Jun 28, 2011·Nanomedicine : Nanotechnology, Biology, and Medicine·Edwin LamersJohn A Jansen
Dec 17, 2009·Dental Materials : Official Publication of the Academy of Dental Materials·Norio HoriTakahiro Ogawa
Feb 24, 2015·Dental Materials : Official Publication of the Academy of Dental Materials·Eiji KatoMasahiro Yamada
Jul 20, 2010·Clinical Oral Implants Research·Giovanni PasseriGuido M Macaluso
Jan 30, 2020·International Journal of Molecular Sciences·Masakazu HasegawaTakahiro Ogawa
Jan 22, 2015·Journal of Biomaterials Applications·Manabu IshijimaTakahiro Ogawa
Jun 15, 2010·Hip International : the Journal of Clinical and Experimental Research on Hip Pathology and Therapy·Stig S JakobsenKjeld Soballe
Feb 3, 2013·Biomaterials Science·Alexey KlymovX Frank Walboomers
Feb 8, 2016·ACS Biomaterials Science & Engineering·Kamolrat MetavarayuthQian Wang
Jun 10, 2014·ACS Applied Materials & Interfaces·Bradley W TuftC Allan Guymon

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