PMID: 6968071Jun 1, 1980Paper

Microtubule assembly and conanavalin A capping in lymphocytes: reappraisal using normal and abnormal human peripheral blood cells

Proceedings of the National Academy of Sciences of the United States of America
J M OliverH M Dosch

Abstract

We have analyzed the assembly of microtubules and the distribution of concanavalin A(Con A)-receptor complexes in the same populations of human peripheral blood T and B lymphocytes. We hoped to resolve the prolonged controversy over the relationship of microtubules to Con A cap formation in lymphocytes and to explain the abnormally high spontaneous and colchicine-induced Con A capping that was observed recently in lymphocytes from a patient with an inherited form of severe combined immunodeficiency disease (SCID) characterized by total immunologic dysfunction despite normal numbers and distribution of T and B cells. The data establish that (i) microtubule disassembly is correlated with enhanced Con A cap formation on normal human lymphocytes; (ii) T and B cells differ significantly from each other and from circulating polymorphonuclear leukocytes with respect to their capping responses after exposure to colchicine; and (iii) there is an abnormal relationship of microtubule assembly to surface topography in the functionally defective SCID cells.

References

Dec 6, 1979·The New England Journal of Medicine·E W GelfandH M Dosch
Jun 1, 1979·Canadian Journal of Biochemistry·C E RuddJ G Kaplan
Jun 1, 1978·The Journal of Cell Biology·R D Berlin, J M Oliver
Jul 1, 1976·The Journal of Cell Biology·M G Mellon, L I Rebhun
May 1, 1973·Proceedings of the National Academy of Sciences of the United States of America·G M EdelmanJ L Wang

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Citations

Feb 1, 1991·Journal of Molecular Recognition : JMR·M TsukadaY Imanishi
Oct 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·M SatakeR B Luftig
Sep 1, 1981·The Journal of Cell Biology·R N MelmedR D Berlin
Dec 1, 1981·The Journal of Cell Biology·J M OliverR D Berlin
Dec 1, 1981·The Journal of Cell Biology·L Y BourguignonY C Hsing
Aug 1, 1981·Experimental Cell Research·T PozzanJ C Metcalfe
Feb 1, 1983·Immunology Today·A H Filipovich, J H Kersey
May 1, 1982·Clinical Immunology and Immunopathology·R A GattiE Boder
Feb 1, 1980·Clinical Immunology and Immunopathology·A CohenE W Gelfand
Jan 1, 1983·Immunology Today·J Braun

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