Microtubule-Binding Proteins as Promising Biomarkers of Paclitaxel Sensitivity in Cancer Chemotherapy

Medicinal Research Reviews
Songbo XieJun Zhou

Abstract

Microtubules, tirelessly animated and highly dynamic structures, are vital for most cellular processes and their intricacies are still being revealed even after a century since their discovery. The importance of microtubules as chemotherapeutic targets cannot be overstated, and their clinical role is unlikely to abate in the near future. Indeed, improved understanding of microtubule biology could herald a new epoch of anticancer drug design by permitting fine-tuning of microtubule-targeting agents, the clinical utility of which is presently often limited by primary or acquired resistance. Paclitaxel, one such agent belonging to the taxane family, has proven a resoundingly successful treatment for many cancer patients; however, for too many others with paclitaxel-refractory tumors, the drug has offered nothing but side effects. Accumulating evidence suggests that microtubule-binding proteins (MBPs) can regulate paclitaxel sensitivity in a wide range of cancer types. Improved understanding of how these proteins can be assayed to predict treatment responses or manipulated pharmacologically to improve clinical outcomes could transform modern chemotherapy and is urgently awaited.

References

Apr 17, 2002·The Journal of Biological Chemistry·Phedra AmayedMarie-France Carlier
Jan 2, 2003·Nature Reviews. Cancer·Dario C Altieri
Apr 18, 2003·Nature·Joe Howard, Anthony A Hyman
Aug 1, 1963·The Journal of Cell Biology·D B SLAUTTERBACK
Jul 2, 2004·Journal of Neurochemistry·Hirotaka YoshidaMichel Goedert
Aug 25, 2004·Proceedings of the National Academy of Sciences of the United States of America·Jennifer L RossD Kuchnir Fygenson
Feb 22, 2005·Current Medicinal Chemistry. Anti-cancer Agents·Jun Zhou, Paraskevi Giannakakou
Mar 2, 2005·The Journal of Biological Chemistry·Fang YangJian Feng
May 26, 2005·Proceedings of the National Academy of Sciences of the United States of America·Roman RouzierLajos Pusztai
Aug 19, 2006·Nucleic Acids Research·Kumar M R BhatVijayasaradhi Setaluri
Dec 19, 2006·Molecular Cancer Therapeutics·Sucharita J Mistry, George F Atweh
Aug 3, 2007·Molecular Cancer Research : MCR·Sucharita J MistryGeorge F Atweh
Jan 29, 2008·The Journal of Biological Chemistry·Jinmin GaoJun Zhou
Mar 7, 2008·Nature Reviews. Molecular Cell Biology·Anna Akhmanova, Michel O Steinmetz
May 15, 2008·Proceedings of the National Academy of Sciences of the United States of America·Lei SunJun Zhou
Jul 18, 2008·Annual Review of Cell and Developmental Biology·Shinya Inoué
Jan 9, 2009·International Journal of Cancer. Journal International Du Cancer·Verena FetzShirley K Knauer
Feb 21, 2009·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Jing LuDihua Yu
Mar 4, 2009·The Journal of Cell Biology·Yulia KomarovaAnna Akhmanova
Jun 23, 2009·EMBO Reports·Kai JiangXuebiao Yao
Jul 28, 2009·Cell·Srinivas HonnappaMichel O Steinmetz
Aug 13, 2009·Cancer Research·Cristiano FerliniGiovanni Scambia
Sep 17, 2009·Biochemical Society Transactions·Babet van der VaartAnne Straube
Dec 8, 2009·The Journal of Pathology·Xin DongJun Zhou
Jan 14, 2010·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Joshua A BauerJennifer A Pietenpol
Jan 14, 2010·Nature Reviews. Molecular Cell Biology·Claire E WalczakAlexey Khodjakov
Jul 2, 2010·The Journal of Pathology·Lei SunJun Zhou
Feb 8, 2011·Hormone Molecular Biology and Clinical Investigation·Surojeet SenguptaV Craig Jordan
Sep 10, 2011·The Journal of Biological Chemistry·Anutosh GangulyFernando Cabral
Oct 13, 2011·The Journal of Pathology·Xiaodong SunJun Zhou

❮ Previous
Next ❯

Citations

Apr 4, 2017·Biochimica Et Biophysica Acta. General Subjects·Jiří ŘehulkaViswanath Das
Apr 8, 2017·Expert Opinion on Pharmacotherapy·C HardinH Cheng
Jun 22, 2018·Thoracic Cancer·Min LiuJun Zhou
May 14, 2016·Journal of Cell Science·Yunfan Yang, Jun Zhou
Sep 8, 2020·Thoracic Cancer·Jingrui LiSongbo Xie
Oct 14, 2017·Journal of Applied Toxicology : JAT·Basem M JaberAyman M Saleh
Jul 26, 2017·Cancer Chemotherapy and Pharmacology·Xingjuan Shi, Xiaoou Sun
Apr 14, 2018·Stem Cell Research & Therapy·Hamideh SalehiValerie Orti
Mar 24, 2020·Acta Pharmacologica Sinica·Ya-Qun ZhouDa-Wei Ye
Aug 23, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Filip BorysHanna Fabczak
Oct 14, 2020·Trends in Molecular Medicine·Sylvie Rodrigues-FerreiraClara Nahmias
Mar 26, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Jiezhu FengHaifeng Yang

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Clinical Cancer Research : an Official Journal of the American Association for Cancer Research
Kumar M R Bhat, Vijayasaradhi Setaluri
Duodecim; lääketieteellinen aikakauskirja
A JekunenS Pyrhönen
© 2021 Meta ULC. All rights reserved