Microtubule-dependent localization of profilin I mRNA to actin polymerization sites in serum-stimulated cells

European Journal of Cell Biology
Anna-Karin Johnsson, Roger Karlsson

Abstract

Specific localization of messenger RNA (mRNA) appears to be a general mechanism to accumulate certain proteins to subcellular compartments for participation in local processes, thereby maintaining cell polarity under strict spatiotemporal control. Transportation of mRNA with associated protein components (RNP granules) by the actin microfilament or the microtubule systems is one important mechanism to achieve this locally distributed protein production. Here we provide evidence for a microtubule-dependent localization of mRNA encoding the actin regulatory protein profilin to sites in mouse embryonic fibroblasts, which express enhanced actin polymerization.

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Citations

Apr 27, 2011·Traffic·Aaron W LiflandPhilip J Santangelo
Jan 27, 2015·Biochemical Society Transactions·Alice Bachmann, Anne Straube
Jun 17, 2016·Molecular Biology of the Cell·Michaela NejedlaRoger Karlsson
Jul 31, 2019·Essays in Biochemistry·Clare Garcin, Anne Straube
Apr 7, 2021·Journal of Cellular Physiology·Roger Karlsson, Pavel Dráber

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