Microtubule-dependent mRNA transport in the model microorganism Ustilago maydis

RNA Biology
Evelyn VollmeisterMichael Feldbrügge

Abstract

Microtubule-dependent trafficking is essential in moving mRNAs over long distances. This transport mechanism regulates important cellular events such as determining polarity and local protein secretion. Key examples are developmental and neuronal processes studied in Drosophila melanogaster, Xenopus laevis as well as in mammalian cells. A simple eukaryotic system to uncover basic mechanisms was missing. Fungal models are generally well suited for this purpose, since transgenic strains can be generated easily by homologous recombination allowing in vivo studies at native expression levels. Substantial advances in understanding Ustilago maydis showed that this fungus fulfils important criteria to serve as model for microtubule-dependent mRNA trafficking. Here, we summarize progress focusing on target mRNAs, RNA localization elements, RNA-binding proteins, mRNPs, molecular motors and microtubule organization. This serves as the basis to discuss the novel mechanism of mRNP hitchhiking on endosomes as well as an unexpected link to unconventional secretion with its implications for applied sciences.

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Citations

Mar 5, 2013·Applied Microbiology and Biotechnology·Michael FeldbrüggeKerstin Schipper
Jul 3, 2013·Annual Review of Microbiology·Meritxell Riquelme
Aug 1, 2015·Current Opinion in Microbiology·Marcus RoperAmy S Gladfelter
Aug 15, 2015·Annual Review of Microbiology·Carl HaagMichael Feldbrügge
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May 27, 2014·Current Opinion in Microbiology·Meritxell Riquelme, Eddy Sánchez-León
Nov 28, 2012·Communicative & Integrative Biology·Vera GöhreMichael Feldbrügge
Jul 11, 2014·Fungal Genetics and Biology : FG & B·Elena Perez-NadalesJürgen Wendland
May 20, 2014·Current Opinion in Microbiology·Gero Steinberg
May 20, 2014·Current Opinion in Microbiology·Jun-ya ShojiKatsuhiko Kitamoto
Nov 12, 2013·Fungal Genetics and Biology : FG & B·Marius TerfrüchteMichael Feldbrügge
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Nov 12, 2019·Biotechnology for Biofuels·Hamed Hosseinpour TehraniNick Wierckx
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