Microtubule Dynamicity Is More Important than Stability in Memory Formation: an In Vivo Study

Journal of Molecular Neuroscience : MN
Deyhim AtarodGholam Hossein Riazi

Abstract

It has been shown that microtubule (MT) activity and dynamics can have huge impacts on synaptic plasticity and memory formation. This is mainly due to various functions of MTs in neurons; MTs are involved in dendritic spine formation, axonal transportation, neuronal polarity, and receptor trafficking. Recent studies from our group and other labs have suggested the possible role of brain MT dynamicity and activity in memory; however, there is a need for more detailed studies regarding this aspect. In this study, we have tried to evaluate the importance of microtubule dynamicity rather than stability in memory formation in vivo. In order to investigate the role of MT stability in memory formation, we treated mice with paclitaxel-a classic microtubule-stabilizing agent. We then studied the behavior of treated animals using Morris water maze (MWM) test. To measure the effect of injected paclitaxel on MT polymerization kinetics, we conducted polymerization assays on brain extracts of the same paclitaxel-treated animals. Our results show that paclitaxel treatment affects animals' memory in a negative way and treated animals behave poorly in MWM compared to control group. In addition, our kinetics studies show that MT stability is sig...Continue Reading

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Citations

Oct 7, 2015·Frontiers in Cellular Neuroscience·Jyoti DubeySandhya P Koushika
Jul 28, 2015·Neurobiology of Learning and Memory·Shusaku Uchida, Gleb P Shumyatsky
Mar 8, 2017·Journal of Neurochemistry·Roland Brandt, Lidia Bakota
Sep 8, 2017·The Journal of Cell Biology·Xiaoyi QuFrancesca Bartolini
Apr 30, 2020·EMBO Molecular Medicine·Lien D Nguyen, Barbara E Ehrlich
Apr 24, 2018·Mediators of Inflammation·Zhao LiXiu-Li Wang
May 1, 2020·British Journal of Pharmacology·Robson da CostaJoão B Calixto
Jan 4, 2020·Journal of Molecular Neuroscience : MN·S Aryana YousefzadehGholam Hossein Riazi
Jun 28, 2021·Molecular Neurodegeneration·Lien D NguyenBarbara E Ehrlich

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