Sep 16, 2020

Microtubule Dynamics and Neuronal Excitability: Advances on Cytoskeletal Components Implicated in Epileptic Phenomena

Cellular and Molecular Neurobiology
Giuditta GambinoPierangelo Sardo

Abstract

Extensive researches have deepened knowledge on the role of synaptic components in epileptogenesis, but limited attention has been devoted to the potential implication of the cytoskeleton. The study of the development of epilepsy and hyperexcitability states involves molecular, synaptic, and structural alterations of neuronal bioelectric activity. In this paper we aim to explore the neurobiological targets involved in microtubule functioning and cytoskeletal transport, i.e. how dynamic scaffolding of microtubules can influence neuronal morphology and excitability, in order to suggest a potential role for microtubule dynamics in the processes turning a normal neuronal network in a hyperexcited one. Pathophysiological alterations of microtubule dynamics inducing neurodegeneration, network remodeling and relative impairment on synaptic transmission were overviewed. Recent researches were reported on the phosphorylation state of microtubule-associated proteins such as tau in neurodegenerative diseases and epileptic states, but also on the effect of microtubule-active agents influencing cytoskeleton destabilization in epilepsy models. The manipulation of microtubule polymerization was found effective in the modulation of hyperexcita...Continue Reading

  • References108
  • Citations

Citations

  • This paper may not have been cited yet.

Mentioned in this Paper

Neuron Remodeling
Tau Proteins
Cytoskeleton
Cognition Disorders
Synapses
Study
Epilepsy
Neurodegenerative Disorders
Structure
Mitochondria

Related Feeds

Basal Forebrain- Circuits

Basal forebrain is a region in the brain important for production of acetylcholine and is the major cholinergic output of the CNS. Discover the latest research on circuits in the basal forebrain here.

Related Papers

Cellular and Molecular Life Sciences : CMLS
Laura PellegriniKirsten Harvey
Frontiers in Cellular Neuroscience
Jyoti DubeySandhya P Koushika
Developmental Dynamics : an Official Publication of the American Association of Anatomists
Amrita RamkumarKassandra M Ori-McKenney
© 2020 Meta ULC. All rights reserved