Microtubule dysfunction precedes transport impairment and mitochondria damage in MPP+ -induced neurodegeneration

Journal of Neurochemistry
Daniele CartelliG Cappelletti

Abstract

Dysfunction of the microtubule (MT) system is an emerging theme in the pathogenesis of Parkinson's disease. This study was designed to investigate the putative role of MT dysfunction in dopaminergic neuron death induced by the neurotoxin 1-methyl-4-phenylpiridinium (MPP(+)). In nerve growth factor-differentiated PC12 cells, we have analyzed post-translational modifications of tubulin known to be associated with differently dynamic MTs and show that MPP(+) causes a selective loss of dynamic MTs and a concomitant enrichment of stable MTs. Through a direct live cell imaging approach, we show a significant reduction of MT dynamics following exposure to MPP(+) and a reorientation of MTs. Furthermore, these alterations precede the impairment of intracellular transport as revealed by changes in mitochondria movements along neurites and their accumulation into varicosities. We have also analyzed activation of caspase 3 and mitochondrial injury, well-known alterations induced by MPP(+), and found that they are noticeable only when MT dysfunction is already established. These data provide the first evidence that axonal transport impairment and mitochondrial damage might be a consequence of MT dysfunction in MPP(+) -induced neurodegenerat...Continue Reading

References

Nov 1, 1978·Biochimica Et Biophysica Acta·L E Marshall, R H Himes
Jun 1, 1991·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·J C Bulinski, G G Gundersen
Mar 5, 1996·Proceedings of the National Academy of Sciences of the United States of America·T G HastingsM J Zigmond
Jan 1, 1997·Annual Review of Cell and Developmental Biology·A Desai, T J Mitchison
Apr 23, 1999·Journal of Neuroscience Research·G CappellettiR Maci
Dec 2, 2000·Nature Neuroscience·R BetarbetJ T Greenamyre
Oct 9, 2001·Cell Biology International·G CappellettiR Maci
Nov 8, 2001·The Journal of Biological Chemistry·Muhammad Abdul AlimKenji Ueda
May 25, 2002·Nature·Charlotte HubbertTso-Pang Yao
Jul 25, 2003·Experimental Cell Research·Graziella CappellettiRosalba Maci
Sep 16, 2003·Neuron·William Dauer, Serge Przedborski
Dec 20, 2003·Nature Reviews. Molecular Cell Biology·Stefan Westermann, Klaus Weber
Jul 24, 2004·Nature Medicine·Ella Bossy-WetzelStuart A Lipton
Mar 2, 2005·The Journal of Biological Chemistry·Fang YangJian Feng
Aug 11, 2005·The Journal of Biological Chemistry·Yong RenJian Feng
Nov 3, 2006·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Jian Feng
Nov 7, 2006·Current Biology : CB·Nathan A ReedKristen J Verhey
Feb 9, 2007·Proceedings of the National Academy of Sciences of the United States of America·G MorfiniS T Brady
Mar 16, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Edda Thies, Eva-Maria Mandelkow
Jul 20, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Myriam Escobar-KhondikerGünter U Höglinger
Mar 13, 2008·Journal of Cell Science·Sarah DunnMichelle Peckham
Jun 19, 2008·Annual Review of Neuroscience·Kurt J De VosChristopher C J Miller
Jun 20, 2008·Journal of Neurochemistry·Yajie LiangBingyin Su
Sep 25, 2008·Proceedings of the National Academy of Sciences of the United States of America·Won-Seok ChoiZhengui Xia
Mar 20, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Chee Yeun ChungOle Isacson

❮ Previous
Next ❯

Citations

Dec 16, 2011·The Journal of Biological Chemistry·Iryna BerezniukLloyd D Fricker
Aug 28, 2012·The Journal of Clinical Investigation·Patrizia FanaraMarc K Hellerstein
Feb 10, 2012·Molecular Neurodegeneration·Jo Ann V Antenor-Dorsey, Karen L O'Malley
Jul 23, 2013·PLoS Biology·Jacob E LazarusErika L F Holzbaur
Jan 4, 2013·PloS One·Paola ZuccottiPaola Riva
May 13, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Jeong Sook Kim-HanKaren L O'Malley
Jan 31, 2012·Experimental Neurology·Robert E Burke, Karen O'Malley
Feb 4, 2014·Antioxidants & Redox Signaling·Juliana Navarro-YepesRodrigo Franco
Mar 15, 2014·Disease Models & Mechanisms·Kelley C O'DonnellAlvaro Sagasti
Feb 24, 2016·Journal of Molecular and Cellular Cardiology·Benjamin M L DrumL Fernando Santana
Jun 7, 2012·Neurobiology of Disease·Victor S Van Laar, Sarah B Berman
May 15, 2012·Trends in Neurosciences·Felipe A Court, Michael P Coleman
Jan 2, 2015·BMC Neuroscience·Jorge A Sierra-FonsecaSukla Roychowdhury
Jan 11, 2011·Biochimica Et Biophysica Acta·A RoviniM Carré
Jun 7, 2015·Cellular and Molecular Neurobiology·Jorgelina M CalandriaNicolas G Bazan
Oct 7, 2015·Frontiers in Cellular Neuroscience·Jyoti DubeySandhya P Koushika
Mar 7, 2015·Archives of Toxicology·Daniel José BarbosaFélix Carvalho
Apr 21, 2016·Progress in Neurobiology·Jessica EiraMárcia Almeida Liz
Aug 21, 2012·Biochimica Et Biophysica Acta·Vivek P PatelCharleen T Chu
Oct 15, 2013·Biochimica Et Biophysica Acta·A R EstevesS M Cardoso
Aug 28, 2012·Biochemical and Biophysical Research Communications·Haruyuki HongoAkinori Akaike
Jul 30, 2014·Frontiers in Cellular Neuroscience·Apostolia Fragkouli, Epaminondas Doxakis
Jan 13, 2015·Oxidative Medicine and Cellular Longevity·Anne-Marie Arel-DubeauMaria-Grazia Martinoli
Aug 16, 2016·Human Molecular Genetics·Emanuela PiermariniFiorella Piemonte
Sep 30, 2016·Frontiers in Cellular Neuroscience·Jayden A ClarkTracey C Dickson
Sep 16, 2016·Scientific Reports·Daniele CartelliGraziella Cappelletti
Oct 21, 2016·Molecular Neurobiology·D Cartelli, G Cappelletti
May 20, 2017·Histochemistry and Cell Biology·Josiah B PassmoreMichael Schrader
Jan 18, 2014·Bioorganic & Medicinal Chemistry·Kurt R BrundenCarlo Ballatore
Nov 15, 2013·Therapeutic Advances in Neurological Disorders·Sara Anna BoniniMaurizio Memo

❮ Previous
Next ❯

Related Concepts

Related Feeds

Apoptotic Caspases

Apoptotic caspases belong to the protease enzyme family and are known to play an essential role in inflammation and programmed cell death. Here is the latest research.