Microtubule polymerization dynamics

Annual Review of Cell and Developmental Biology
A Desai, T J Mitchison

Abstract

The polymerization dynamics of microtubules are central to their biological functions. Polymerization dynamics allow microtubules to adopt spatial arrangements that can change rapidly in response to cellular needs and, in some cases, to perform mechanical work. Microtubules utilize the energy of GTP hydrolysis to fuel a unique polymerization mechanism termed dynamic instability. In this review, we first describe progress toward understanding the mechanism of dynamic instability of pure tubulin and then discuss the function and regulation of microtubule dynamic instability in living cells.

References

Dec 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·T David-PfeutyD Pantaloni
Jan 1, 1978·International Review of Cytology·M W Kirschner
Nov 1, 1977·Cell·B M SpiegelmanM W Kirschner
Nov 1, 1976·Journal of Molecular Biology·A Wegner
Jul 1, 1975·Journal of Theoretical Biology·F Oosawa
Dec 5, 1975·Journal of Molecular Biology·M W KirschnerR C Williams
Jan 1, 1992·The Journal of Cell Biology·A PereiraL S Goldstein
Oct 1, 1992·Molecular Biology of the Cell·D N DrechselM W Kirschner
Dec 1, 1992·Molecular Biology of the Cell·T J Mitchison
Jan 1, 1992·Cell Motility and the Cytoskeleton·E M Mandelkow, E Mandelkow
Jan 1, 1992·Annual Review of Biophysics and Biomolecular Structure·H P Erickson, E T O'Brien
Feb 1, 1992·Current Opinion in Cell Biology·M Caplow
Feb 1, 1992·Current Opinion in Cell Biology·J E ErikssonR D Goldman
Jun 1, 1992·The Journal of Cell Biology·D ChrétienR H Wade
Jan 1, 1991·Cell Motility and the Cytoskeleton·R G Burns
Sep 1, 1991·Journal of Neuroscience Research·P W BaasM M Black
Jan 1, 1991·Annual Review of Cell Biology·V I Gelfand, A D Bershadsky
Feb 1, 1991·Current Opinion in Cell Biology·M F Carlier
Sep 1, 1991·The Journal of Cell Biology·E M MandelkowR A Milligan
Jun 1, 1991·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·J C Bulinski, G G Gundersen
Jan 1, 1991·Biology of the Cell·D Chrétien, R H Wade
Oct 1, 1991·The Journal of Cell Biology·E M Tanaka, M W Kirschner
Aug 1, 1991·Trends in Biochemical Sciences·A Sobel
Jan 1, 1991·Cell Motility and the Cytoskeleton·W A VoterH P Erickson
Jan 1, 1990·Advances in Biophysics·H Hotani, H Miyamoto
Dec 1, 1990·The Journal of Cell Biology·M H BréE Karsenti
Jan 30, 1990·Biochemical and Biophysical Research Communications·M R MejillanoR H Himes
Jul 17, 1990·Biochemistry·E T O'BrienH P Erickson
Oct 3, 1989·Biochemistry·M CaplowE D Salmon
Jan 1, 1989·International Review of Cytology·M F Carlier

❮ Previous
Next ❯

Citations

Apr 22, 1999·Microscopy Research and Technique·M ShirasuC E Walczak
Jan 5, 2000·Cell Motility and the Cytoskeleton·B Govindan, R D Vale
Mar 8, 2000·Cell Motility and the Cytoskeleton·T VolbergB Geiger
Sep 2, 1998·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·A Desai, T J Mitchison
Nov 1, 2000·The Anatomical Record·C E Schutt, U Lindberg
Apr 3, 2002·Bulletin of Mathematical Biology·Ivan V Maly
Apr 25, 2000·Cell Biology International·J C SissonW Sullivan
Oct 9, 2001·Cell Biology International·G CappellettiR Maci
Dec 11, 1999·Cell Biochemistry and Biophysics·W V NicholsonE Nogales
Aug 21, 2010·Cellular and Molecular Life Sciences : CMLS·Linxia ZhangChristina Chan
May 28, 2013·Naunyn-Schmiedeberg's Archives of Pharmacology·Sofian S MohamedAbdul M Gbaj
Mar 3, 2005·Histochemistry and Cell Biology·M O J Olson, Miroslav Dundr
Apr 14, 2011·Pflügers Archiv : European journal of physiology·Ed White
May 29, 2008·Journal of Neural Transmission·Anna FilipekGrazyna Niewiadomska
Dec 24, 2004·Journal of Molecular Modeling·Suzanne L CunninghamBilly W Day
Mar 11, 2010·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Oveis KarimaAli Akbar Moosavi Movahedi
Feb 8, 2007·Journal of Plant Research·Takahiro Hamada
Apr 25, 2012·Journal of Computer-aided Molecular Design·Joseph R AndréPhilippe Manivet
Aug 12, 2009·Journal of Biological Physics·Avner PrielHoracio F Cantiello
May 21, 2005·Journal of Neurocytology·Nicholas A DiProsperoDanilo A Tagle
Jun 27, 2012·Pharmaceutical Research·Melissa M GajewskiJack A Tuszynski
Jul 5, 2012·Pharmaceutical Research·Chien-Ming LiJames T Dalton
Feb 9, 2011·Bulletin of Mathematical Biology·Manoj Gopalakrishnan, Bindu S Govindan
Aug 31, 2012·Cell Biochemistry and Biophysics·Weiling HongJianping Xie
Jul 19, 2008·Journal of Molecular Neuroscience : MN·Tal Shprung, Illana Gozes
Sep 24, 2010·Breast Cancer : the Journal of the Japanese Breast Cancer Society·Gerald M Higa
Jan 27, 2012·Cellular Oncology (Dordrecht)·Alex D ChackoS E Hilary Russell
Feb 26, 2013·European Journal of Medicinal Chemistry·Hala Bakr El-Nassan
Mar 5, 2004·Fungal Genetics and Biology : FG & B·Xin Xiang, Reinhard Fischer
Dec 9, 2003·Journal of Molecular Biology·A KrebsA Hoenger
Jan 27, 2004·Journal of Molecular Biology·Oleg Galkin, Peter G Vekilov
Jun 14, 2005·Trends in Cell Biology·Camelia Iancu-Rubin, George F Atweh
May 7, 2003·Biochemical and Biophysical Research Communications·Aya KawachiTomohiko J Itoh
Jun 26, 2001·Brain Research·Y GuoS B Udin
Aug 31, 2000·Cell·R Heald
Jul 23, 2003·Trends in Pharmacological Sciences·Paula M ChecchiHarish C Joshi

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Methods Mentioned

BETA
electron crystallography
X-ray
nucleotide exchange
light scattering
electron microscopy
optical diffraction
fluorescence imaging
fluorescence microscopy
saturation stoichiometry
immunodepletion

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