PMID: 37363Jun 1, 1979

Microvascular and clinical effects of altered peritoneal dialysis solutions

Kidney International
F N MillerA J Ghods

Abstract

Blood flow in the peritoneum is one of the more important factors governing the efficiency of peritoneal dialysis. Yet there have been no previous studies which relate alterations and control of the peritoneal microcirculation to dialysis efficiency. Thus, we used closed-circuit television microscopy to quantitative the in vivo response (changes in diameter) to dialysis solutions of the small arteries on the mesothelial surface of the rat cecum and arterioles of the rat cremaster muscle. These responses were correlated wiht solute clearances from multiple peritoneal dialysis performed in humans. In the cremaster, a transient constriction was followed by a prolonged dilation. pH adjustments of the dialysis solution from 5.6 to 7.4 had no effect on the microvascular response and no effect on solute clearances during human peritoneal dialysis. In the cecum, dialysis solution caused a prolonged dilation which reached a maximum in about 10 min. Since dilation appears to be an important determinant of solute clearances during human peritoneal dialysis, the effects of a vasodilator, sodium nitroprusside, were determined. Sodium nitroprusside decreased the time to maximal dilation, which correlated clinically with an increased solute c...Continue Reading

References

Jan 1, 1989·International Urology and Nephrology·N Y IlkerS Cetin
Sep 1, 1984·Clinical and Experimental Pharmacology & Physiology·D N GrangerP R Kvietys
Aug 5, 2005·Journal of the American Society of Nephrology : JASN·El Rasheid ZakariaR Neal Garrison
Jan 1, 1982·Kidney International·N AlaviC J Bentzel
Sep 1, 1981·Kidney International·F N MillerD B Andersen
Mar 1, 1984·Kidney International·F N MillerJ N Moore
Jun 1, 1994·Kidney International·Dirk G StruijkL Arisz
Sep 1, 1984·Kidney International·J T Dulaney, F E Hatch
Nov 1, 1981·Kidney International·C B DunhamA M Mattocks
Mar 1, 1987·Kidney International·T N LevinK D Nolph
Dec 1, 1985·Journal of Pediatric Surgery·M D KleinJ R Wesley
May 11, 2006·American Journal of Physiology. Renal Physiology·Michael F FlessnerKimberly Credit
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Mar 29, 2001·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·C E DoumaR T Krediet
Oct 1, 2008·NDT Plus·Dirk G Struijk
Sep 1, 2016·Pleura and Peritoneum·Wiebke SolassMartin Schenk
Nov 17, 2020·Peritoneal Dialysis International : Journal of the International Society for Peritoneal Dialysis·Jacek WaniewskiBengt Lindholm

Citations

Nov 1, 1978·The Journal of Clinical Investigation·C S Liang, J M Lowenstein
Jan 1, 1978·Journal of Dialysis·P HirszelM Chamberlin
Aug 15, 1977·European Journal of Pharmacology·F N Miller, D L Wiegman
Jan 1, 1976·Microvascular Research·B R Duling, E Staples

Related Concepts

Dialysis Solutions
Vasodilator [EPC]
Sodium Nitroprusside
Arterial System
Blood Vessel
Pathological Dilatation
Blood Flow
Vasodilator Agents
Structure of Arteriole
Rat Cecum

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