Microvascular and Macrovascular Abnormalities and Cognitive and Physical Function in Older Adults: Cardiovascular Health Study

Journal of the American Geriatrics Society
Dae Hyun KimLewis A Lipsitz

Abstract

To evaluate and compare the associations between microvascular and macrovascular abnormalities and cognitive and physical function Cross-sectional analysis of the Cardiovascular Health Study (1998-1999). Community. Individuals with available data on three or more of five microvascular abnormalities (brain, retina, kidney) and three or more of six macrovascular abnormalities (brain, carotid artery, heart, peripheral artery) (N = 2,452; mean age 79.5). Standardized composite scores derived from three cognitive tests (Modified Mini-Mental State Examination, Digit-Symbol Substitution Test, Trail-Making Test (TMT)) and three physical tests (gait speed, grip strength, 5-time sit to stand) Participants with high microvascular and macrovascular burden had worse cognitive (mean score difference = -0.30, 95% confidence interval (CI) = -0.37 to -0.24) and physical (mean score difference = -0.32, 95% CI = -0.38 to -0.26) function than those with low microvascular and macrovascular burden. Individuals with high microvascular burden alone had similarly lower scores than those with high macrovascular burden alone (cognitive function: -0.16, 95% CI = -0.24 to -0.08 vs -0.13, 95% CI = -0.20 to -0.06; physical function: -0.15, 95% CI = -0.22 to ...Continue Reading

References

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May 28, 2014·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Dae Hyun KimLewis A Lipsitz

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Citations

Jul 12, 2018·PloS One·Bamini GopinathPaul Mitchell
Apr 29, 2019·GeroScience·Tamas CsipoAndriy Yabluchanskiy
Jul 10, 2019·Applied Neuropsychology. Adult·Rihin ChavdaJared F Benge
Nov 21, 2020·Journal of the American Geriatrics Society·Florent GuervilleUNKNOWN MAPT/DSA group
Oct 20, 2020·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Michelle C OddenAdolfo Correa
Aug 11, 2018·The American Journal of Geriatric Psychiatry : Official Journal of the American Association for Geriatric Psychiatry·Patrick J SmithAndrew Sherwood
Apr 24, 2021·American Journal of Hematology·Chau VuJohn C Wood
Aug 3, 2021·Annals of Epidemiology·Lindsay M MillerMichelle C Odden

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