Microvascular blood flow dynamics associated with photodynamic therapy, pulsed dye laser irradiation and combined regimens

Lasers in Surgery and Medicine
Tia SmithKristen M Kelly

Abstract

Previous in vitro studies demonstrated the potential utility of benzoporphyrin derivative monoacid ring A (BPD) photodynamic therapy (PDT) for vascular destruction. Moreover, the effects of PDT were enhanced when this intervention was followed immediately by pulsed dye laser (PDL) irradiation (PDT/PDL). We further evaluate vascular effects of PDT alone, PDL alone and PDT/PDL in an in vivo rodent dorsal skinfold model. A dorsal skinfold window chamber was installed surgically on female Sprague-Dawley rats. One milligram per kilogram of BPD solution was administered intravenously via a jugular venous catheter. Evaluated interventions were: control (no BPD, no light), PDT alone (576 nm, 16 minutes exposure time, 15 minutes post-BPD injection, 10 mm spot), PDL alone at 7 J/cm2 (585 nm, 1.5 ms pulse duration, 7 mm spot), PDL alone at 10 J/cm2, PDT/PDL (PDL at 7 J/cm2), and PDT/PDL (PDL at 10 J/cm2). To assess changes in microvascular blood flow, laser speckle imaging was performed before, immediately after, and 18 hours post-intervention. Epidermal irradiation was accomplished without blistering, scabbing or ulceration. A reduction in perfusion was achieved in all intervention groups. PDT/PDL at 7 J/cm2 resulted in the greatest redu...Continue Reading

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Citations

Apr 6, 2012·Medical & Biological Engineering & Computing·Kausik BasakPranab Kumar Dutta
Apr 1, 2010·Chemical Reviews·Jonathan P CelliTayyaba Hasan
Nov 5, 2010·Physics in Medicine and Biology·J C Ramírez-San-JuanB Choi
Dec 4, 2008·Lasers in Medical Science·Matthijs DraijerWiendelt Steenbergen
Jul 10, 2010·Journal of Biomedical Optics·Shiyong ZhaoXunbin Wei
Jul 19, 2014·The Journal of Investigative Dermatology·Kristen M KellyBernard Choi
Jan 9, 2010·Journal of Photochemistry and Photobiology. B, Biology·E DebefveT Krueger
Nov 26, 2009·Photodiagnosis and Photodynamic Therapy·Joshua A TournasKristen M Kelly
Jul 28, 2007·The Journal of Investigative Dermatology·Bernard ChoiJustin Lotfi
Sep 5, 2008·Photodiagnosis and Photodynamic Therapy·Kristen Kelly
Oct 28, 2008·Lasers in Surgery and Medicine·Jennifer ChannualKristen M Kelly
Jul 4, 2012·Lasers in Surgery and Medicine·Masayoshi KawakuboMichael R Hamblin
Feb 16, 2012·Lasers in Surgery and Medicine·Wesley J MoyBernard Choi
Jan 26, 2012·Lasers in Surgery and Medicine·Wangcun JiaJ Stuart Nelson
Mar 22, 2014·Drug Development Research·Karin E ThompsonCharles R Yates
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Oct 19, 2016·Lasers in Surgery and Medicine·Linzhuang XingGuoxiang Wang
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