Abstract
Previous in vitro studies demonstrated the potential utility of benzoporphyrin derivative monoacid ring A (BPD) photodynamic therapy (PDT) for vascular destruction. Moreover, the effects of PDT were enhanced when this intervention was followed immediately by pulsed dye laser (PDL) irradiation (PDT/PDL). We further evaluate vascular effects of PDT alone, PDL alone and PDT/PDL in an in vivo rodent dorsal skinfold model. A dorsal skinfold window chamber was installed surgically on female Sprague-Dawley rats. One milligram per kilogram of BPD solution was administered intravenously via a jugular venous catheter. Evaluated interventions were: control (no BPD, no light), PDT alone (576 nm, 16 minutes exposure time, 15 minutes post-BPD injection, 10 mm spot), PDL alone at 7 J/cm2 (585 nm, 1.5 ms pulse duration, 7 mm spot), PDL alone at 10 J/cm2, PDT/PDL (PDL at 7 J/cm2), and PDT/PDL (PDL at 10 J/cm2). To assess changes in microvascular blood flow, laser speckle imaging was performed before, immediately after, and 18 hours post-intervention. Epidermal irradiation was accomplished without blistering, scabbing or ulceration. A reduction in perfusion was achieved in all intervention groups. PDT/PDL at 7 J/cm2 resulted in the greatest redu...Continue Reading
References
Jan 1, 1990·Lasers in Surgery and Medicine·A OrensteinM W Berns
Dec 21, 1988·Journal of the National Cancer Institute·J S NelsonM W Berns
Jan 1, 1997·Physics in Medicine and Biology·M J van GemertJ S Nelson
May 1, 1997·Plastic and Reconstructive Surgery·C H LinD T Hsu
Apr 17, 1999·British Journal of Cancer·V H FingarT J Wieman
Jan 29, 2000·The Journal of Investigative Dermatology·M M TsoukasN Kollias
Mar 18, 2000·Archives of Ophthalmology·M SickenbergN M Bressler
Jul 13, 2000·Archives of Dermatology·R G GeronemusA N Kauvar
Apr 11, 2001·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·A K DunnD A Boas
Sep 27, 2001·Lasers in Surgery and Medicine·G VargasA J Welch
Jan 5, 2002·Physiological Measurement·J D Briers
Mar 21, 2002·The British Journal of Dermatology·D W EdströmA M Ros
Dec 12, 2002·Retina·Jean-Marie Houle, H Andrew Strong
Apr 1, 2003·Photochemical & Photobiological Sciences : Official Journal of the European Photochemistry Association and the European Society for Photobiology·Marie J Hammer-WilsonMichael W Berns
Sep 25, 2003·Plastic and Reconstructive Surgery·Mübin HoşnuterAhmet Işikdemir
Mar 9, 2004·Lasers in Surgery and Medicine·Sol KimelJ Stuart Nelson
May 13, 2004·Photochemistry and Photobiology·Xiaodong ZhouTayyaba Hasan
Jun 25, 2004·Lasers in Surgery and Medicine·Kristen M KellyJ Stuart Nelson
Aug 18, 2004·Microvascular Research·Bernard ChoiJ Stuart Nelson
Feb 11, 2005·Lasers in Surgery and Medicine·Guillermo AguilarJ Stuart Nelson
Feb 11, 2005·Lasers in Surgery and Medicine·Guillermo AguilarJ Stuart Nelson
May 4, 2005·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Guoqiang YuTheresa M Busch
Aug 16, 2005·The Journal of Investigative Dermatology·Philipp BabilasChristoph Abels
Sep 21, 2005·Archives of Facial Plastic Surgery·Kristen M KellyJ Stuart Nelson
Citations
Feb 18, 2011·Lasers in Medical Science·Naiyan HuangYing Gu
Apr 6, 2012·Medical & Biological Engineering & Computing·Kausik BasakPranab Kumar Dutta
Apr 1, 2010·Chemical Reviews·Jonathan P CelliTayyaba Hasan
Nov 5, 2010·Physics in Medicine and Biology·J C Ramírez-San-JuanB Choi
Apr 28, 2012·Photochemistry and Photobiology·Haixia QiuNaiyan Huang
Aug 27, 2013·Lasers in Medical Science·Jie RenYing Gu
Dec 4, 2008·Lasers in Medical Science·Matthijs DraijerWiendelt Steenbergen
Jul 10, 2010·Journal of Biomedical Optics·Shiyong ZhaoXunbin Wei
Jul 19, 2014·The Journal of Investigative Dermatology·Kristen M KellyBernard Choi
Jan 9, 2010·Journal of Photochemistry and Photobiology. B, Biology·E DebefveT Krueger
Nov 26, 2009·Photodiagnosis and Photodynamic Therapy·Joshua A TournasKristen M Kelly
Jul 28, 2007·The Journal of Investigative Dermatology·Bernard ChoiJustin Lotfi
Sep 5, 2008·Photodiagnosis and Photodynamic Therapy·Kristen Kelly
Oct 28, 2008·Lasers in Surgery and Medicine·Jennifer ChannualKristen M Kelly
Jul 4, 2012·Lasers in Surgery and Medicine·Masayoshi KawakuboMichael R Hamblin
Oct 29, 2011·The Journal of Dermatology·Qiang XiaoBiao Cheng
Feb 16, 2012·Lasers in Surgery and Medicine·Wesley J MoyBernard Choi
Jan 26, 2012·Lasers in Surgery and Medicine·Wangcun JiaJ Stuart Nelson
Mar 1, 2012·Lasers in Surgery and Medicine·M A D PetersJ F Beek
Mar 22, 2014·Drug Development Research·Karin E ThompsonCharles R Yates
Feb 19, 2010·Lasers in Surgery and Medicine·Wangcun JiaJ Stuart Nelson
Mar 26, 2016·IEEE Journal of Selected Topics in Quantum Electronics : a Publication of the IEEE Lasers and Electro-optics Society·Bernard ChoiJ Stuart Nelson
Apr 14, 2016·Photodiagnosis and Photodynamic Therapy·Defu ChenYing Gu
Oct 19, 2016·Lasers in Surgery and Medicine·Linzhuang XingGuoxiang Wang
Sep 13, 2006·Journal of Biomedical Optics·Bernard ChoiJ Stuart Nelson
Feb 21, 2018·Journal of Cosmetic and Laser Therapy : Official Publication of the European Society for Laser Dermatology·Emma Bergqvist, Gunnar Bergqvist
Nov 20, 2008·Archives of Facial Plastic Surgery·Edward C Wu, Brian J F Wong
May 10, 2016·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Sujay Khandpur, Vinod K Sharma
Jun 8, 2015·The Cancer Journal·Srivalleesha MallidiTayyaba Hasan
May 24, 2008·International Journal of Cancer. Journal International Du Cancer·Bin ChenBrian W Pogue
Jun 1, 2010·The Journal of Dermatological Treatment·Wei LiKenji Hashimoto