Microvascular blood flow in scalds in children and its relation to duration of wound healing: A study using laser speckle contrast imaging

Burns : Journal of the International Society for Burn Injuries
Robin MirdellErik Tesselaar

Abstract

Microvascular perfusion changes in scalds in children during the first weeks after injury is related to the outcome of healing, and measurements of perfusion, based on laser Doppler imaging, have been used successfully to predict the need for excision and grafting. However, the day-to-day changes in perfusion during the first weeks after injury have not to our knowledge been studied in detail. The aim of this study, based on a conservative treatment model where excision and grafting decisions were delayed to day 14 after injury, was to measure changes in perfusion in scalds using laser speckle contrast imaging (LSCI) during the first three weeks after injury. We measured perfusion with LSCI in 34 patients at regular intervals between 6h after injury until complete reepithelialization or surgery. Duration of healing was defined as the time to complete reepithelialization. Less perfusion, between 6 and 96h after injury, was associated with longer duration of healing with the strongest association occurring between 72 and 96h. Burns that healed within 14 days had relatively high initial perfusion, followed by a peak and subsequent slow decrease. Both the maximum perfusion and the time-to-peak were dependent on the severity of the ...Continue Reading

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Citations

Oct 7, 2016·Burns : Journal of the International Society for Burn Injuries·Sarah LonieRodrigo P Teixeira
Mar 11, 2017·Acta Oncologica·Erik TesselaarAlexandru Dasu
Aug 7, 2019·Journal of Biomedical Optics·Wido HeemanE Christiaan Boerma
Jul 16, 2020·Skin Research and Technology : Official Journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI)·Erik Tesselaar, Simon Farnebo
Jun 13, 2019·Journal of Burn Care & Research : Official Publication of the American Burn Association·Marco Domenico CirilloTuan D Pham
Nov 3, 2017·Scientific Reports·E A MannohA Mahadevan-Jansen
Feb 26, 2020·Plastic and Reconstructive Surgery. Global Open·Johan ZöttermanErik Tesselaar
Oct 28, 2019·Biomedical Optics Express·Ben LertsakdadetBernard Choi
Aug 25, 2018·Lasers in Medical Science·Tanvi PedanekarAmit Sengupta
Nov 17, 2020·Journal of Biomedical Optics·Martin HultmanIngemar Fredriksson
May 6, 2021·Burns : Journal of the International Society for Burn Injuries·Marco Domenico CirilloTuan D Pham
May 20, 2021·Burns : Journal of the International Society for Burn Injuries·K J ZhengA Pijpe

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