PMID: 8458773Feb 1, 1993Paper

Microvascular damage in the cortex of cat brain from middle cerebral artery occlusion and reperfusion

Journal of Applied Physiology
D F WilsonJ H Greenberg

Abstract

Oxygen-dependent quenching of phosphorescence provides an extraordinarily powerful method for examining the effects of ischemia/hypoxia on the cortex of the brain. Video camera technology has permitted imaging, through a window in the skull, of the phosphorescence of an oxygen probe, Pd meso-tetra-(4-carboxyphenyl)-porphine, bound to albumin in the blood of anesthetized animals. Images of the phosphorescence taken at different times after the flash of excitation light were used to generate high-resolution two-dimensional maps of the oxygen pressure. These maps show that cortical oxygenation is spatially heterogeneous and that there is dynamic time-dependent modulation of regional oxygen pressures. When the middle cerebral artery was occluded, the region for which it supplied blood became hypoxic, the severity of the hypoxia varying among animals. Release after 60 min of occlusion resulted in a rapid rise of the oxygen pressure to above-normal levels followed by onset of a delayed period of hypoxia. This period is characterized by generally low tissue oxygen pressures with local regions of more severe hypoxia. The delayed period of hypoxia appears to result from damage to the microvasculature, and this microvascular damage is pr...Continue Reading

Citations

Jul 20, 2002·Photochemistry and Photobiology·Egbert G MikCan Ince
Feb 1, 1996·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·D P Boisvert, E D Hall
Dec 8, 2004·Journal of Applied Physiology·Lisa S ZiemerDavid F Wilson
Nov 1, 1996·Journal of Applied Physiology·M Sinaasappel, C Ince
Jun 18, 2015·Angewandte Chemie·Emmanuel RoussakisConor L Evans
Jun 26, 1998·Journal of Photochemistry and Photobiology. B, Biology·B W McIlroyA J MacRobert

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