Microvascular disease: what does the UKPDS tell us about diabetic retinopathy?

Diabetic Medicine : a Journal of the British Diabetic Association
E M Kohner

Abstract

Background The UK Prospective Diabetes Study (UKPDS) was a randomised controlled clinical study which looked at the effect of improved blood glucose and blood pressure control on macro- and microvascular complications in Type 2 diabetes. Retinopathy was the commonest microvascular outcome and this paper looks at this complication. Methods Newly diagnosed diabetic patients were randomised to intensive or conventional glycaemic control and a subset of hypertensive patients to tight or less tight blood pressure control. Patients were seen every 3 months in study clinics and retinopathy was assessed by adjudicated grading of triennial colour retinal photographs. Photocoagulation treatment, vitreous haemorrhage and cataract extraction were predefined UKPDS endpoints. Observational analyses of the data were used to examine the relationship of updated mean glycated haemoglobin (HbA(1c)) and mean blood pressure levels to retinopathy outcomes. Results The UKPDS showed that both improved glucose control and improved blood pressure control reduced the risk of retinopathy, with a linear relationship between the log hazard ratio for retinopathy and both updated mean HbA(1c) and updated mean blood pressure. A 1% decrement in HbA(1c) equated ...Continue Reading

References

Jan 1, 1979·Diabetes·J Scott, P L Poffenbarger
Aug 19, 1976·The New England Journal of Medicine·R J KoenigA Cerami
Apr 25, 2001·Diabetic Medicine : a Journal of the British Diabetic Association·E M KohnerUNKNOWN UK Prospective Diabetes Study (IKPDS) Group
Dec 13, 2002·Journal of Diabetes and Its Complications·Richard J StevensUNKNOWN UK Prospective Diabetes Study (UKPDS58)
Nov 10, 2004·Archives of Ophthalmology·David R MatthewsUNKNOWN UK Prospective Diabetes Study Group
Aug 10, 2005·Journal of the Renin-angiotensin-aldosterone System : JRAAS·Anne Katrin SjølieUNKNOWN DIRECT Programme Study Group
Sep 23, 2006·Ophthalmology·UNKNOWN PKC-DRS2 GroupXin Eric Zhi
Jan 29, 2008·Current Diabetes Reviews·Rakesh ChibberEva M Kohner

❮ Previous
Next ❯

Citations

Nov 18, 2009·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Robert SteigerwaltFrank Schönlau
Oct 23, 2013·PloS One·Miguel Á Salinero-FortUNKNOWN MADIABETES Group
Mar 13, 2012·International Journal of Molecular Medicine·Sergey LupachykIrina G Obrosova
Apr 25, 2009·Clinics in Laboratory Medicine·Michael L Merchant, Jon B Klein
Feb 17, 2009·Diabetes/metabolism Research and Reviews
Sep 22, 2010·Diabetic Medicine : a Journal of the British Diabetic Association·J GenzA Icks
Feb 18, 2011·Clinical & Experimental Optometry : Journal of the Australian Optometrical Association·Ka Man Carmen Lee, Wing Man Rita Sum
Dec 18, 2013·Diabetes/metabolism Research and Reviews·Tali Cukierman-Yaffe
Jun 12, 2010·Diabetic Medicine : a Journal of the British Diabetic Association·M VestgaardE R Mathiesen
Apr 5, 2016·Journal of Diabetes Investigation·Ronald C W Ma
Jul 26, 2012·ISRN Endocrinology·Lisa R SimmonsElizabeth L Chua
May 7, 2015·Diabetes Research and Clinical Practice·Shitaye AlemuElisabeth R Trimble
Sep 27, 2016·Diabetes Research and Clinical Practice·Linda Hill, Lydia E Makaroff
Oct 21, 2016·Journal of Diabetes Research·Pedro Romero-ArocaRaquel Verges
Dec 4, 2016·The British Journal of Ophthalmology·Shigeta ArichikaNagahisa Yoshimura
Oct 12, 2010·Diabetes & Vascular Disease Research : Official Journal of the International Society of Diabetes and Vascular Disease·Mark E Cooper
Feb 24, 2018·Asia-Pacific Journal of Ophthalmology·Kevin Miller, Jorge A Fortun
Jun 23, 2010·Nature Reviews. Endocrinology·Anne HiukkaMarja-Riitta Taskinen
Feb 2, 2019·Current Pharmaceutical Design·Victor M Villegas, Stephen G Schwartz
Nov 19, 2010·Arquivos brasileiros de endocrinologia e metabologia·Murilo José MichelsLetícia Maria Furlanetto
Jan 13, 2017·Evidence-based Complementary and Alternative Medicine : ECAM·Yue ZhaoXiaofei An
Oct 8, 2018·Journal of Molecular Neuroscience : MN·Harshini Chakravarthy, Vasudharani Devanathan
Jan 23, 2021·The Journal of Clinical Endocrinology and Metabolism·Tali Cukierman-YaffeOscar Benavente
Jan 1, 2021·Diabetes, Metabolic Syndrome and Obesity : Targets and Therapy·Guang-Ran YangLin Li
Apr 6, 2021·Diabetes, Metabolic Syndrome and Obesity : Targets and Therapy·Motasem Al-LatayfehAmjad A Al Shdaifat
Aug 28, 2021·Diagnostics·Nicoleta AntonIonela Nechita-Dumitriu

❮ Previous
Next ❯

Related Concepts

Related Feeds

CV Disorders & Type 2 Diabetes

This feed focuses on the association of cardiovascular diseases in patients with type 2 diabetes.

Related Papers

Value in Health : the Journal of the International Society for Pharmacoeconomics and Outcomes Research
Joyce A CramerPeter K Wong
Diabetes & Metabolism Journal
Dae Jung Kim
© 2022 Meta ULC. All rights reserved