PMID: 3766755Oct 1, 1986Paper

Microvascular distribution of coronary vascular resistance in beating left ventricle

The American Journal of Physiology
W M ChilianM L Marcus

Abstract

To determine the distribution of resistance in the coronary vasculature, measurements of microvascular pressure and diameter were obtained with vasomotor tone intact and during coronary dilation produced by papaverine. We studied anesthetized, open-chest cats and used jet ventilation synchronized to the cardiac cycle to eliminate respiratory-induced cardiac motion. The system for measuring microvascular pressure compensated for cardiac motion with stroboscopic illumination of the microvessels and a computer-controlled electromechanical micromanipulator that moved a micropipette in synchrony with the heart. Pressures were measured with the servonull technique, and diameters were measured via a video system. Resistance was estimated from the pressure gradient from the aorta to a particular class (size) of coronary microvessel. During control conditions, with coronary vasomotor tone intact, myocardial perfusion was 139 +/- 9 ml X min-1 X 100 g-1 and was increased to 339 +/- 52 during papaverine infusion (P less than 0.05). During control conditions (mean arterial pressure 70-80 mmHg), approximately 25% of total coronary resistance was proximal to 200-microns diameter arterioles and approximately 20% was produced by arterioles betw...Continue Reading

Citations

Nov 22, 2000·American Journal of Physiology. Heart and Circulatory Physiology·N SpyrouP G Camici
Sep 29, 2000·American Journal of Physiology. Heart and Circulatory Physiology·K G LampingF M Faraci
Mar 4, 2008·American Journal of Physiology. Heart and Circulatory Physiology·B A KaufmannH P Brunner-La Rocca
May 14, 2011·Journal of Applied Physiology·Cristine L Heaps, Janet L Parker
Jul 26, 2014·Journal of Applied Physiology·Mina A HannaJudy M Muller-Delp
Mar 16, 2017·The Journal of Physiology·Kazuki HottaJudy M Muller-Delp
Oct 13, 2018·American Journal of Physiology. Heart and Circulatory Physiology·Abigail V GilesRobert S Balaban
Oct 6, 1999·Circulation·D W SteppW M Chilian
Oct 23, 2002·Journal of Applied Physiology·M Harold LaughlinChristopher R Woodman
Sep 15, 2001·American Journal of Physiology. Heart and Circulatory Physiology·J D Symons, S Schaefer
May 11, 2002·American Journal of Physiology. Heart and Circulatory Physiology·Annemiek J M CornelissenJos A E Spaan
Sep 15, 2001·American Journal of Physiology. Heart and Circulatory Physiology·C L OltmanK C Dellsperger
Jun 8, 2001·News in Physiological Sciences : an International Journal of Physiology Produced Jointly by the International Union of Physiological Sciences and the American Physiological Society·Ulrich Pohl, Cor de Wit
Nov 14, 2003·American Journal of Physiology. Heart and Circulatory Physiology·Naris Thengchaisri, Lih Kuo
Feb 22, 2003·American Journal of Physiology. Heart and Circulatory Physiology·John J BosnjakDavid D Gutterman
Oct 4, 2006·Physiological Reviews·Nico WesterhofPieter Sipkema
Jul 21, 2009·American Journal of Physiology. Heart and Circulatory Physiology·Lori S KangJudy M Muller-Delp
Jan 21, 2010·Circulation. Cardiovascular Imaging·Dudley J Pennell
Jan 31, 2016·American Journal of Physiology. Heart and Circulatory Physiology·Adam G GoodwillGregory M Dick
Sep 28, 2000·Journal of Applied Physiology·J I Hoffman, W M Chilian
Sep 23, 2000·American Journal of Physiology. Endocrinology and Metabolism·R F AmmarK C Dellsperger
Nov 22, 2000·American Journal of Physiology. Heart and Circulatory Physiology·D MerkusW M Chilian
Nov 8, 2005·American Journal of Physiology. Heart and Circulatory Physiology·Robert ParentMichel Lavallée
Jul 12, 2003·American Journal of Physiology. Heart and Circulatory Physiology·Kathryn G LampingRobert J Tomanek
Feb 19, 2005·Arteriosclerosis, Thrombosis, and Vascular Biology·Erion QamiraniTravis W Hein
Jul 16, 2008·Physiological Reviews·Dirk J Duncker, Robert J Bache
Mar 13, 2012·American Journal of Physiology. Heart and Circulatory Physiology·Jonathan M YoungYoram Lanir
Dec 26, 2009·American Journal of Physiology. Heart and Circulatory Physiology·Fen GaoDaphne Merkus
Dec 19, 2019·Frontiers in Immunology·Dean Philip John Kavanagh, Neena Kalia
Jan 25, 2000·American Journal of Physiology. Heart and Circulatory Physiology·T W HeinL Kuo

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.