Microvascular disturbance with decreased pericyte coverage is prominent in the ventral horn of patients with amyotrophic lateral sclerosis

Amyotrophic Lateral Sclerosis & Frontotemporal Degeneration
Misaki YamaderaSaburo Sakoda

Abstract

In amyotrophic lateral sclerosis (ALS) there is emerging evidence for vasculature disturbance. The aim of this study was to investigate the area of predominant vasculature disturbance in ALS. We used immunohistochemistry to quantitatively evaluate the microvascular density (MVD) and pericyte coverage (PC) in the lumbar spinal cord of 25 ALS patients and six controls. In controls, MVD was almost equal in the ventral horn (VH) and dorsal horn (DH). In the VH of ALS, MVD was significantly increased, and PC was significantly decreased compared with the DH in ALS and the VH in controls (p < 0.001), possibly reflecting that PC is an essential requirement for the vasculature in the VH. We then found a significant relationship between the severity of aberrant angiogenesis and the use of artificial respiratory support (ARS). In conclusion, vasculature disturbance is observed in all ALS patients including patients with ARS. Therefore, breakdown of the blood-spinal cord barrier due to aberrant angiogenesis with decreased PC may be responsible for the predominant neuronal death in the VH in ALS.

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Citations

Mar 20, 2018·Current Opinion in Supportive and Palliative Care·Alexandra M DurrantNicholas Beazley-Long
Oct 4, 2018·Physiological Reviews·Melanie D SweeneyBerislav V Zlokovic
Dec 29, 2019·Neuropathology : Official Journal of the Japanese Society of Neuropathology·Motoko Niida-KawaguchiNoriyuki Shibata
Apr 7, 2018·F1000Research·Nicholas Beazley-LongLucy F Donaldson
Jan 10, 2021·Journal of Neuropathology and Experimental Neurology·Isidro FerrerMónica Povedano
Mar 30, 2021·Frontiers in Cellular Neuroscience·Hannah C Bennett, Yongsoo Kim
Jul 25, 2021·International Journal of Molecular Sciences·Ying-Chieh WuŠárka Lehtonen
Aug 15, 2021·Acta Neuropathologica Communications·Mariángeles KovacsEmiliano Trias
Aug 28, 2021·Acta Neuropathologica Communications·Sarah WatersEmma Scotter

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