PMID: 15238822Jul 9, 2004Paper

Microvascular dysfunction in angiographically normal or mildly diseased coronary arteries predicts adverse cardiovascular long-term outcome

Coronary Artery Disease
Martina B BrittenVolker Schächinger

Abstract

To study the role of coronary flow reserve for the prediction of long-term cardiovascular event rate. Observational, longitudinal. Single-center, coronary vasomotor testing at university hospital. One hundred and twenty patients with angiographically normal or minimally diseased coronary vessel. Coronary flow reserve was assessed by intracoronary Doppler and quantitative coronary angiography. Cardiovascular events during follow-up (6.5+/-3 years, range 14-125 months) were defined as sudden death, myocardial infarction, unstable angina, ischemic stroke or the need for revascularization by percutaneous transluminal coronary angioplasty or coronary as well as peripheral bypass surgery. Reduced coronary flow reserve was significantly associated with a poor long-term outcome: cardiovascular events occurred in seven (18%) patients in the lowest tertile of coronary flow reserve compared with four patients in the middle tertile (10%) and two patients in the upper tertile (5%) (P=0.019 by Kaplan-Meier analysis). The multivariate Cox proportional hazard model revealed coronary flow reserve as an independent predictor of prognosis (P=0.017) in addition to angiographic evidence of atherosclerosis (P=0.047) and arterial hypertension (P=0.01...Continue Reading

References

Sep 1, 1992·The Journal of Clinical Investigation·J P CookeM E Billingham
Nov 1, 1990·Circulation·R F WilsonD D Laxson
Mar 1, 1984·Journal of the American College of Cardiology·D A WeinerF Tristani
Jan 1, 1996·Arteriosclerosis, Thrombosis, and Vascular Biology·R C CandipanJ P Cooke
Oct 1, 1996·Arteriosclerosis, Thrombosis, and Vascular Biology·F TroncA Tedgui
Dec 1, 1996·Journal of the American College of Cardiology·J Niebauer, J P Cooke
Jun 5, 1999·Journal of Internal Medicine·M B BrittenV Schächinger
Nov 14, 2000·Circulation Research·H Cai, D G Harrison
Feb 7, 2001·Arteriosclerosis, Thrombosis, and Vascular Biology·S KawashimaM Yokoyama
Jun 13, 2001·Circulation·J P Cooke, P S Tsao
Mar 1, 2002·Journal of the American College of Cardiology·Steven A J ChamuleauJan J Piek
Aug 7, 2002·Circulation·Julian P J HalcoxArshed A Quyyumi

❮ Previous
Next ❯

Citations

Mar 6, 2007·European Journal of Nuclear Medicine and Molecular Imaging·Thomas H SchindlerHeinrich R Schelbert
Aug 7, 2007·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Thomas H SchindlerHeinrich R Schelbert
Nov 21, 2007·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Thomas H Schindler, Heinrich H Schelbert
Aug 24, 2012·European Heart Journal·Joerg HerrmannAmir Lerman
Sep 10, 2013·European Heart Journal·Enrique GutiérrezFrancisco Fernández-Avilés
Sep 8, 2005·Southern Medical Journal·Steven B Karch
Jun 15, 2010·EuroIntervention : Journal of EuroPCR in Collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology·Narbeh MelikianBernard de Bruyne
Nov 14, 2013·Cardiology Research and Practice·Arturo Orea-TejedaZuilma Vázquez-Ortíz
Jun 21, 2014·Seminars in Nuclear Medicine·Thomas H SchindlerVasken Dilsizian
Feb 24, 2012·Netherlands Heart Journal : Monthly Journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation·I A C VermeltfoortP G H M Raijmakers
Dec 25, 2010·Atherosclerosis·Emmanouil I SkalidisPanos E Vardas
Dec 3, 2014·Journal of the American Society of Hypertension : JASH·Faika C CiftciFiliz Yanik
Feb 14, 2015·JACC. Cardiovascular Imaging·Mark A MarinescuJamieson M Bourque
Aug 30, 2011·The American Journal of Cardiology·Alberto Ranieri De CaterinaFilippo Crea
Nov 16, 2007·Atherosclerosis·Huseyin BozbasHaldun Muderrisoglu
Apr 3, 2007·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·Wendy S TzouJames H Stein
Jan 1, 2007·Journal of the American Society of Hypertension : JASH·Ernesto L Schiffrin
Jul 22, 2015·International Journal of Cardiology·Jamie LaylandKeith Oldroyd
Oct 26, 2005·Diabetic Medicine : a Journal of the British Diabetic Association·A NemesM Csanády
Sep 7, 2007·Clinical Cardiology·Mustafa CaliskanHaldun Muderrisoglu
Mar 13, 2012·Echocardiography·Asli I AtarMehmet E Korkmaz
Dec 5, 2012·The Journal of Clinical Hypertension·Huseyin BozbasHaldun Muderrisoglu
Sep 5, 2015·Journal of the American College of Cardiology·Jaskanwal D SaraAmir Lerman
Apr 20, 2006·Atherosclerosis·Dogan ErdoganHaldun Muderrisoglu
Sep 14, 2015·European Heart Journal·Giampaolo NiccoliFilippo Crea

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiovascular Inflammation

Inflammation plays a significant role in the development of cardiovascular diseases, an understanding of these endogenous processes is critical for evaluating the risks and potential treatment strategies. Discover the latest research on cardiovascular inflammation here.

Brain Ischemia

Brain ischemia is a condition in which there is insufficient blood flow to the brain to meet metabolic demand. Discover the latest research on brain ischemia here.